N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine

Product Name: N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine
CAS No.: 474-74-8
Chemical Name: N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine
Synonyms: Glycine gallate;Lithocholylglycine;Glycinocholic acid;Glycolithocholic-d4 Acid;Ursodeoxycholic Impurity 13;Urosodeoxycholic Acid Impurity 13;Glycolithocholic Acid in Methanol;Lithocholic acid glycine conjugate;Glycolithocholic acid, 10 mM in DMSO;Glycolithocholic Acid MaxSpec? Standard
CBNumber: CB91236072
Molecular Formula: C26H43NO4
Formula Weight: 433.63
MOL File: 474-74-8.mol

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N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine Property

Melting point:: 212-214 °C
Boiling point:: 546.95°C (rough estimate)
Density: 1.0738 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Refrigerator
solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form: Solid
pka: 3.58±0.10(Predicted)
color: White to Off-White
InChIKey: XBSQTYHEGZTYJE-LNYAHCOINA-N
SMILES: C[C@]12CC[C@]3([H])[C@]4(CC[C@@H](O)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)NCC(=O)O)C |&1:1,4,6,9,12,16,18,22,24,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21723
Product name: Glycolithocholic Acid
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 21723
Product name: Glycolithocholic Acid
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 21723
Product name: Glycolithocholic Acid
Purity: ≥98%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 21723
Product name: Glycolithocholic Acid
Purity: ≥98%
Packaging: 25mg
Price: $267
Updated: 2024/03/01

Usbiological

Product number: 281262
Product name: Lithocholylglycine
Packaging: 2mg
Price: $360
Updated: 2021/12/16

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N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine Chemical Properties,Usage,Production

Description

Glycolithocholic acid is a glycine-conjugated form of the secondary bile acid lithocholic acid . It is increased in the liver of mice fed a diet supplemented with ursodeoxycholic acid . Glycolithocholic acid levels are decreased in the plasma following subcutaneous administration of PEG-obestatin(Cys¹⁰, Cys¹³), a modified peptide hormone, in lean or diet-induced obese mice. Serum glycolithocholic acid levels increase with age in children.

Uses

A metabolite in human hepatic bile. A lithocholic acid analog that inhibit sialyltransferase.

Definition

ChEBI: The glycine conjugate of lithocholic acid.

in vivo

The concentrations of Glycolithocholic acid in ulcerative colitis (UC) patients were significantly lower than those in healthy controls (HCs)^[2].

IC 50

Microbial Metabolite

References

[1] P. LEFEBVRE. Role of bile acids and bile acid receptors in metabolic regulation.[J]. Physiological reviews, 2009, 89 1 1: 147-191. DOI: 10.1152/physrev.00010.2008
[2] YOUCAI ZHANG Curtis D K. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice.[J]. Journal of Lipid Research, 2010, 51 11: 3230-3242. DOI: 10.1194/jlr.m007641
[3] ELAINE COWAN. Treatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics.[J]. Metabolomics, 2016, 12: 124. DOI: 10.1007/s11306-016-1063-0
[4] RICHARD D SEMBA. Environmental Enteric Dysfunction Is Associated With Altered Bile Acid Metabolism.[J]. Journal of Pediatric Gastroenterology and Nutrition, 2017, 64 4: 536-540. DOI: 10.1097/mpg.0000000000001313

N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine Suppliers

Canada 1 China 85 India 3 United States 5 Global 94

J & K SCIENTIFIC LTD.

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Adamas Reagent, Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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View Lastest Price from N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine 474-74-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2000
Release date: 2025-08-22

Shaanxi Xianhe Biotech Co., Ltd

Product: Glycinocholic acid 474-74-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 1000KG
Release date: 2025-04-21

Shaanxi Dideu Medichem Co. Ltd

Product: Lithocholylglycine 474-74-8
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-08-02

474-74-8, N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) GlycineRelated Search:

3ALPHA-HYDROXY-5BETA-CHOLAN 24-OIC ACID N-[CARBOXYMETHYL]AMIDE 3-SULFATE DISODIUM SALT SODIUM GLYCOCHOLATE HYDRATE, 98 GLYCOCHOLIC ACID-13C1 (GLYCYL-1-13C) LITHOCHOLIC ACID Glycocholic acid GLYCODEOXYCHOLIC ACID GLYCODEOXYCHOLIC ACID SODIUM SALT GLYCOCHOLIC ACID SODIUM SALT Glycochenodeoxycholic acid sodium salt N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine GLYCOURSODEOXYCHOLIC ACID, SODIUM SALT GLYCOLITHOCHOLIC ACID, SODIUM SALT Glycoursodeoxycholic acid glycohyodeoxycholic acid 5-BETA-CHOLANIC ACID-3-ALPHA, 6-ALPHA-DIOL N-(CARBOXYMETHYL)-AMIDE SODIUM SALT 3ALPHA-HYDROXY-5BETA-CHOLAN-24-OIC ACID N-[CARBOXYMETHYL]AMIDE ETHYL ESTER GLYCOCHOLIC ACID, [GLYCINE-1-14C] GLYCOCHOLIC ACID-(GLYCINE-1-13C) MONOHYDRATE

Lithocholylglycine

N-[(3α,5β)-3-Ηydroxy-24-oxocholan-24-yl]glycine

Glycolithocholic-d4 Acid

Lithocholic acid glycine conjugate

N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine

Ursodeoxycholic Impurity 13

Glycine, N-[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]-

Glycolithocholic Acid MaxSpec? Standard

Glycine, N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-

primary,glycine,Glycolithocholic acid,non-alcoholic,NASH,colitis,sclerosing,inhibit,ulcerative,bile,steatohepatitis,PSC,acid,diagnose,Endogenous Metabolite,Inhibitor,cholangitis

Urosodeoxycholic Acid Impurity 13

Chenodeoxycholic Acid Impurity 16 (Lithocholylglycine)

5β-CHOLANIC ACID-3α-OL N-(CARBOXYMETHYL)-AMIDE

N-[(3a,5b)-3-hydroxy-24-0xocholan-24-yl]-(9C1) Glycine

Glycine gallate

Glycinocholic acid

Glycolithocholic Acid in Methanol

5β-Cholan-24-Oic Acid N-(Carboxymethyl)-Amide-3α-Ol

Glycolithocholic acid, 10 mM in DMSO

474-74-8

C26H43NO4

Inhibitors

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids