4-(4-chlorophenyl)sulfonylaniline
- Product Name
- 4-(4-chlorophenyl)sulfonylaniline
- CAS No.
- 7146-68-1
- Chemical Name
- 4-(4-chlorophenyl)sulfonylaniline
- Synonyms
- NSC 51990;NSC 23812;Dapsone Impurity 2;Dapsone Impurity 5;Dapsone EP Impurity E;4-(4-chlorophenyl)sulfonylaniline;4-Amino-4''-Chlorodiphenyl Sulphone;p-[(p-Chlorophenyl)sulfonyl]aniline;4-AMinophenyl 4-chlorophenyl Sulfone;Dapsone Aniline Chlorophenyl Impurity
- CBNumber
- CB91257732
- Molecular Formula
- C12H10ClNO2S
- Formula Weight
- 267.73
- MOL File
- 7146-68-1.mol
4-(4-chlorophenyl)sulfonylaniline Property
- Melting point:
- 184-185 °C
- Boiling point:
- 466.4±30.0 °C(Predicted)
- Density
- 1.394±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 0.84±0.10(Predicted)
- color
- Off-White to Light Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A603775
- Product name
- 4-Amino-4''-chlorodiphenylSulfone
- Packaging
- 1g
- Price
- $1390
- Updated
- 2021/12/16
- Product number
- 1093AC
- Product name
- 4-((4-Chlorophenyl)sulfonyl)aniline
- Packaging
- 5g
- Price
- $658
- Updated
- 2021/12/16
- Product number
- HCH0121249
- Product name
- 4-(4-CHLORO-BENZENESULFONYL)PHENYLAMINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $750.75
- Updated
- 2021/12/16
- Product number
- HCH0121249
- Product name
- 4-(4-CHLORO-BENZENESULFONYL)PHENYLAMINE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $2425.5
- Updated
- 2021/12/16
- Product number
- CD12040290
- Product name
- 4-((4-Chlorophenyl)sulfonyl)aniline
- Purity
- 97%
- Packaging
- 10g
- Price
- $743
- Updated
- 2021/12/16
4-(4-chlorophenyl)sulfonylaniline Chemical Properties,Usage,Production
Uses
4-Amino-4'-chlorodiphenyl sulfone is a substituted 4-aminodiphenylsulfone as Escherichia coli dihydropteroate synthase inhibitor.
Synthesis
6630-10-0
7146-68-1
Step 2. N-[4-(4-Chlorophenyl)sulfonylphenyl]acetamide (5.5 g, 0.014 mol) was dissolved in a mixture of concentrated hydrochloric acid (70 mL) and ethanol (70 mL), and the reaction was refluxed overnight. The progress of the reaction was monitored by thin layer chromatography (unfolding reagent: petroleum ether/ethyl acetate = 2:1, Rf = 0.3) to confirm the completion of the reaction. The reaction mixture was concentrated under reduced pressure and the residue was neutralized with saturated sodium bicarbonate solution to pH>7 and subsequently extracted with ethyl acetate (80 mL x 3). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 4-((4-chlorophenyl)sulfonyl)aniline (4.1 g, 87% yield) as a light brown solid.
References
[1] Patent: WO2014/26039, 2014, A2. Location in patent: Paragraph 0191
[2] Gazzetta Chimica Italiana, 1949, vol. 79, p. 621,625
4-(4-chlorophenyl)sulfonylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(4-chlorophenyl)sulfonylaniline manufacturers
- Product
- 4-(4-chlorophenyl)sulfonylaniline 7146-68-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02