4-Pyridinecarbonitrile,2-formyl-(9CI)
- Product Name
- 4-Pyridinecarbonitrile,2-formyl-(9CI)
- CAS No.
- 116308-38-4
- Chemical Name
- 4-Pyridinecarbonitrile,2-formyl-(9CI)
- Synonyms
- 2-forMylisonicotinonitrile;2-Formylpyridine-4-carbonitrile;2-forMyl-4-pyridinecarbonitrile;4-Cyanopyridine-2-carboxaldehyde;4-Cyano-2-pyridinecarboxaldehyde;4-Pyridinecarbonitrile, 2-formyl-;4-Pyridinecarbonitrile,2-formyl-(9CI);4-Pyridinecarbonitrile,2-formyl-(9CI) ISO 9001：2015 REACH
- CBNumber
- CB91272591
- Molecular Formula
- C7H4N2O
- Formula Weight
- 132.12
- MOL File
- 116308-38-4.mol
4-Pyridinecarbonitrile,2-formyl-(9CI) Property
- Boiling point:
- 201.0±20.0℃ (760 Torr)
- Density
- 1.24±0.1 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 75.4±21.8℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.45±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- 2671AA
- Product name
- 2-Formylisonicotinonitrile
- Packaging
- 100mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- CHM0388228
- Product name
- 2-FORMYLISONICOTINONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.97
- Updated
- 2021/12/16
- Product number
- 143881
- Product name
- 2-Formylisonicotinonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $916
- Updated
- 2021/12/16
- Product number
- 143881
- Product name
- 2-Formylisonicotinonitrile
- Purity
- 95%
- Packaging
- 5g
- Price
- $1832
- Updated
- 2021/12/16
- Product number
- D1526
- Product name
- 2-formyl-4-Pyridinecarbonitrile
- Purity
- 97.00%
- Packaging
- 10G
- Price
- $1910
- Updated
- 2021/12/16
4-Pyridinecarbonitrile,2-formyl-(9CI) Chemical Properties,Usage,Production
Synthesis
51454-63-8
116308-38-4
Oxalyl chloride (13.2 mL, 150 mmol) was dissolved in anhydrous dichloromethane (86 mL) under nitrogen protection and cooled to -78°C. Dimethyl sulfoxide (21.2 mL) was added slowly dropwise over 20 min and the reaction mixture was stirred at -78°C for 15 min. Subsequently, 4-cyanopyridine-2-methanol (4.0 g, 30 mmol) dissolved in anhydrous dichloromethane (60 mL) was added dropwise to the reaction mixture over a period of 5 min and stirring was continued for 2 h while maintaining -78°C and a nitrogen atmosphere. Formation of a white solid precipitate was observed during the reaction. The reaction temperature was raised to -55°C and triethylamine (6.15 mL, 450 mmol) was added dropwise over 15 minutes. The cooling bath was removed and the reaction mixture was allowed to warm naturally to room temperature over a period of 2 hours. Upon completion of the reaction, the mixture was diluted with dichloromethane (400 mL), washed successively with brine (2 x 50 mL), and the aqueous phase was then back-extracted with dichloromethane (3 x 50 mL). All organic layers were combined and concentrated under reduced pressure to give a light yellow solid product. The product did not require further purification and showed a single peak by LC-MS analysis with a retention time (RT) of 2.53 min and a mass spectrometry (M + H) peak located at m/z 133.0 in quantitative yield.
References
[1] Patent: WO2006/21801, 2006, A1. Location in patent: Page/Page column 65-66
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[3] Patent: US6043248, 2000, A
[4] Patent: WO2006/21801, 2006, A1. Location in patent: Page/Page column 46-47
[5] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 559 - 576
4-Pyridinecarbonitrile,2-formyl-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
4-Pyridinecarbonitrile,2-formyl-(9CI) Suppliers
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- Country
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View Lastest Price from 4-Pyridinecarbonitrile,2-formyl-(9CI) manufacturers
- Product
- 4-Pyridinecarbonitrile,2-formyl-(9CI) 116308-38-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 4-Pyridinecarbonitrile,2-formyl-(9CI) 116308-38-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-11-19