5-Pyrimidinol,4,6-dichloro-(9CI)
- Product Name
- 5-Pyrimidinol,4,6-dichloro-(9CI)
- CAS No.
- 425394-89-4
- Chemical Name
- 5-Pyrimidinol,4,6-dichloro-(9CI)
- Synonyms
- 4,6-dichloropyriMidin-5-ol;4,6-Dichloro-5-pyrimidinol;5-Pyrimidinol, 4,6-dichloro-;4,6-Dichloro-5-hydroxypyrimidine;5-Pyrimidinol,4,6-dichloro-(9CI)
- CBNumber
- CB91292289
- Molecular Formula
- C4H2Cl2N2O
- Formula Weight
- 164.98
- MOL File
- 425394-89-4.mol
5-Pyrimidinol,4,6-dichloro-(9CI) Property
- Boiling point:
- 242℃
- Density
- 1.679
- Flash point:
- 100℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.66±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- FD143367
- Product name
- 4,6-Dichloropyrimidin-5-ol
- Packaging
- 100mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- FD143367
- Product name
- 4,6-Dichloropyrimidin-5-ol
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- FD143367
- Product name
- 4,6-Dichloropyrimidin-5-ol
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FD143367
- Product name
- 4,6-Dichloropyrimidin-5-ol
- Packaging
- 1g
- Price
- $352
- Updated
- 2021/12/16
- Product number
- HCH0365385
- Product name
- 4,6-DICHLOROPYRIMIDIN-5-OL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.77
- Updated
- 2021/12/16
5-Pyrimidinol,4,6-dichloro-(9CI) Chemical Properties,Usage,Production
Synthesis
5018-38-2
425394-89-4
The general procedure for the synthesis of 4,6-dichloropyrimidin-5-ol from 4,6-dichloro-5-methoxypyrimidine was as follows: to a stirred solution of 4,6-dichloro-5-methoxypyrimidine (50 g, 0.27 mol) in dichloroethane (800 mL) was added anhydrous aluminum chloride (50.48 g, 0.411 mol) in one go at 0 °C. The reaction mixture was stirred vigorously at 50°C for 6 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and a 1 M aqueous HCl solution (400 mL) was slowly added, followed by methanol (100 mL). The mixture was stirred vigorously at room temperature for 10 minutes, diluted with water and extracted with ethyl acetate. The organic layers were combined, washed with saturated sodium bicarbonate solution and then dried over anhydrous sodium sulfate. The dried organic layer was filtered and concentrated to give 4,6-dichloropyrimidin-5-ol (41 g, 91.11% yield).UPLC analysis: calculated value of C4H2Cl2N2O was 164.97 and measured value was 165.9.
References
[1] Patent: WO2018/208987, 2018, A2. Location in patent: Paragraph 00178
[2] Patent: US2015/152068, 2015, A1. Location in patent: Paragraph 0366; 0367; 0368
[3] Patent: WO2015/79417, 2015, A1. Location in patent: Page/Page column 76; 77
[4] Patent: WO2016/79669, 2016, A1. Location in patent: Page/Page column 45
[5] Patent: WO2016/164580, 2016, A1. Location in patent: Page/Page column 280
5-Pyrimidinol,4,6-dichloro-(9CI) Preparation Products And Raw materials
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View Lastest Price from 5-Pyrimidinol,4,6-dichloro-(9CI) manufacturers
- Product
- 5-Pyrimidinol,4,6-dichloro-(9CI) 425394-89-4
- Price
- US $0.00-0.00/G
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 20TONS
- Release date
- 2025-11-04