3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI)
- Product Name
- 3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI)
- CAS No.
- 100189-16-0
- Chemical Name
- 3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI)
- Synonyms
- 5-(1-Hydroxyethyl);a,6-diMethyl-3-PyridineMethanol;1-(6-Methyl-3-pyridinyl)ethanol;α,6-DiMethyl-3-pyridineMethanol;3-Pyridinemethanol, α,6-dimethyl-;3-Pyridinemethanol, a,6-dimethyl-;5-(1-Hydroxyethyl)-2-methylpyridine;3-(1-Hydroxyethyl)-6-Methylpyridine;6-5-(1-Hydroxyethyl)-2-methylpyridine;dl-2-Methyl-5-[1-hydroxyethyl]pyridine
- CBNumber
- CB91297794
- Molecular Formula
- C8H11NO
- Formula Weight
- 137.18
- MOL File
- 100189-16-0.mol
3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI) Property
- Boiling point:
- 135 °C(Press: 10 Torr)
- Density
- 1.055±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 13.77±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M326310
- Product name
- 1-(6-Methyl-3-pyridinyl)ethanol
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 0117AA
- Product name
- 5-(1-Hydroxyethyl)-2-methylpyridine
- Packaging
- 1g
- Price
- $171
- Updated
- 2021/12/16
- Product number
- CS-B0462
- Product name
- 3-Pyridinemethanol,a,6-dimethyl-
- Purity
- 99.0%
- Packaging
- 5g
- Price
- $308
- Updated
- 2021/12/16
- Product number
- CS-B0462
- Product name
- 3-Pyridinemethanol,a,6-dimethyl-
- Purity
- 99.0%
- Packaging
- 100mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- CS-B0462
- Product name
- 3-Pyridinemethanol,a,6-dimethyl-
- Purity
- 99.0%
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI) Chemical Properties,Usage,Production
Uses
5-(1-Hydroxyethyl)-2-methylpyridine is an intermediate used in the synthesis of metabolites of the antidiabetic, antihyperglycemic agent Pioglitazone (P471000).
Synthesis
36357-38-7
56019-64-8
General procedure for the synthesis of 6-methyl-3-(1-hydroxyethyl)pyridine from 1-(6-methylpyridin-3-yl)ethanone: Sodium borohydride (2.3 g, 0.06 mol) was added in batches to a solution of 1-(6-methylpyridin-3-yl)ethanol (160 ml) of 1-(6-methylpyridin-3-yl)ethanone (16.4 g, 0.121 mol) at 30 °C, maintaining a constant temperature and continuously stirring the reaction mixture. After 1 hour of reaction, the reaction mixture was diluted with saturated sodium bicarbonate solution (2 x 200 ml) and subsequently extracted with dichloromethane (2 x 500 ml). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give a light yellow oil. The crude product was purified by fast column chromatography (eluent: 5% methanol/dichloromethane) to afford 6-methyl-3-(1-hydroxyethyl)pyridine (17.0 g, two-step yield 93%) as a pale yellow oil.ES-MS [M + 1]+ : 138.1. 1H NMR (400 MHz, CDCl3): δ 8.35 (d, J = 2.0 Hz, 1H), δ 7.63 (dd, J = 8.0,2.4 Hz, 1H), 7.12 (d, J = 8.0 Hz, 1H), 4.89 (q, J = 6.5 Hz, 1H), 3.30 (brs, 1H), 2.50 (s, 3H), 1.48 (d, J = 6.5 Hz, 3H).
References
[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 26, p. 5053 - 5063
[2] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 12, p. 2168 - 2172
[3] Chemische Berichte, 1947, vol. 80, p. 502,505
[4] Patent: WO2009/80637, 2009, A1. Location in patent: Page/Page column 32
[5] Patent: WO2015/150476, 2015, A1. Location in patent: Page/Page column 23; 24
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View Lastest Price from 3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI) manufacturers
- Product
- 5-(1-HYDROXYETHYL)-2-METHYLPYRIDINE 100189-16-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11