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3-bromo-1-methyl-1H-pyrazole

Product Name
3-bromo-1-methyl-1H-pyrazole
CAS No.
151049-87-5
Chemical Name
3-bromo-1-methyl-1H-pyrazole
Synonyms
3-Bromo-1-methyl-1H-pyrazole;3-Bromo-1-methylpyrazole;CAS:151049-87-5;3-bromo-1-methyl-(9CI);3-bromo-1-methylpyrrole;1-Methyl-3-bromopyrazole;3-BroMo-1-Methyl-1H-pyraz...;1H-Pyrazole, 3-bromo-1-methyl;1H-Pyrazole,3-bromo-1-methyl-(9CI);3-Bromo-1-methyl-1H-pyrazole
CBNumber
CB91299561
Molecular Formula
C4H5BrN2
Formula Weight
161
MOL File
151049-87-5.mol
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3-bromo-1-methyl-1H-pyrazole Property

Density 
1.585 g/mL at 25 °C
refractive index 
n20/D1.528
Flash point:
106℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
liquid
pka
-0.27±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
Boiling point:
204-210°C/760 mmHg
InChI
InChI=1S/C4H5BrN2/c1-7-3-2-4(5)6-7/h2-3H,1H3
InChIKey
ZGEVJEQMVRIEPX-UHFFFAOYSA-N
SMILES
N1(C)C=CC(Br)=N1
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Safety

RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00074
Product name
3-Bromo-1-methyl-1H-pyrazole
Purity
Aldrich
Packaging
1g
Price
$30.7
Updated
2025/07/31
Sigma-Aldrich
Product number
760390
Product name
3-Bromo-1-methyl-1H-pyrazole
Purity
96%
Packaging
500mg
Price
$79
Updated
2025/07/31
Matrix Scientific
Product number
070535
Product name
3-Bromo-1-methyl-1H-pyrazole
Purity
95%
Packaging
5g
Price
$87
Updated
2021/12/16
Ark Pharm
Product number
P000647354
Product name
3-Bromo-1-methyl-1H-pyrazole
Purity
98%
Packaging
5g
Price
$68
Updated
2021/12/16
Ark Pharm
Product number
P000647354
Product name
3-Bromo-1-methyl-1H-pyrazole
Purity
98%
Packaging
1g
Price
$23
Updated
2021/12/16
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3-bromo-1-methyl-1H-pyrazole Chemical Properties,Usage,Production

Uses

3-bromo-1-methyl-1H-pyrazole is mainly used in chemical manufacturing or organic synthesis. Due to its structural properties it can be used for regioselective synthesis.

Synthesis

1904-31-0

151049-87-5

General procedure for the synthesis of 3-bromo-1-methylpyrrole from N-methyl-3-aminopyrazole: A) Synthesis of 3-bromo-1-methyl-1H-pyrazole: To a solution of 1-methyl-1H-pyrazol-3-amine (2.00 g) in hydrobromic acid (14.0 mL) was added slowly and dropwise to an aqueous solution (2.06 mL) of sodium nitrite (1.56 g) under the cooling of an ice bath. The reaction mixture was stirred under ice bath cooling for 30 minutes before a solution of copper(I) bromide (7.39 g) in hydrobromic acid (14.0 mL) was slowly added. The reaction mixture was continued to be stirred under ice bath cooling for 30 hours. Upon completion of the reaction, the reaction solution was neutralized with saturated aqueous sodium bicarbonate and diluted with dichloromethane. The insoluble material was removed by filtration, and the filtrate was washed sequentially with water and saturated brine and dried over anhydrous magnesium sulfate. After evaporation of the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to afford 3-bromo-1-methylpyrrole (818 mg). The product was characterized by 1H NMR (400 MHz, CDCl3): δ3.88 (3H, s), 6.25 (1H, d, J=2.4 Hz), 7.25 (1H, d, J=2.0 Hz).

References

[1] Journal of Organic Chemistry, 1991, vol. 56, # 22, p. 6313 - 6320
[2] Patent: EP2818473, 2014, A1. Location in patent: Paragraph 0577
[3] Synthesis (Germany), 2015, vol. 47, # 5, p. 679 - 691

3-bromo-1-methyl-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-bromo-1-methyl-1H-pyrazole Suppliers

China 155 Europe 1 India 2 Switzerland 1 United Kingdom 1 United States 12 Global 172
CHEMSTEP
Tel
--
Fax
--
Email
info@chemstep.com
Country
Europe
ProdList
6143
Advantage
51
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View Lastest Price from 3-bromo-1-methyl-1H-pyrazole manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
1H-Pyrazole,3-bromo-1-methyl-(9CI) 151049-87-5
Price
US $90.00-900.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-13
Shanghai Rlavie Technology Co ltd
Product
3-Bromo-1-methylpyrazole 151049-87-5
Price
US $0.00-0.00/kg
Min. Order
0.0001kg
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-05-09
Career Henan Chemical Co
Product
1H-Pyrazole,3-bromo-1-methyl-(9CI) 151049-87-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-05-24

151049-87-5, 3-bromo-1-methyl-1H-pyrazoleRelated Search:

1-Methylpyrazole 3,4,5-TRIBROMO-1-(4-NITROPHENYL)-1H-PYRAZOLE 4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINE N-(2-FLUOROBENZOYL)-N'-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]UREA DIETHYL 2-([4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINO]METHYLIDENE)MALONATE 2-([4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINO]METHYLIDENE)MALONONITRILE N1-[2-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ETHYL]-4-CHLOROBENZAMIDE N-(4-CHLOROPHENYL)-N'-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]UREA 3,4-DIBROMO-1,5-DIMETHYL-1H-PYRAZOLE N1-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]ACETAMIDE N1-[2-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ETHYL]-4-CHLOROBENZENE-1-SULFONAMIDE N1,N1-DIMETHYL-N'1-[2-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ETHYL]ETHANIMIDAMIDE N-(4-CHLOROPHENYL)-N'-[2-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ETHYL]THIOUREA N-METHYL-N'-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]UREA ETHYL 2-CYANO-3-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINO]ACRYLATE N1-(4-CHLOROBENZYLIDENE)-4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINE N1-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]-4-CHLOROBENZENE-1-SULFONAMIDE N1-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]-4-CHLOROBENZAMIDE

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