5-vinyl-2'-deoxyuridine

Product Name: 5-vinyl-2'-deoxyuridine
CAS No.: 55520-67-7
Chemical Name: 5-vinyl-2'-deoxyuridine
Synonyms: 5-Vinyl-dUrd;Tylosin Impurity 7;BrivudineImpurity10;5-vinyldeoxyuridine;2'-Deoxy-5-vinyluridine;5-vinyl-2'-deoxyuridine;2'-Deoxy-5-ethenyluridine;Uridine, 2'-deoxy-5-ethenyl-;5-Vinyl-2'-deoxyuridine (5-VdU);5-Vinyl-2′,-deoxyuridine (5-VdU) (10 mg)
CBNumber: CB91312370
Molecular Formula: C11H14N2O5
Formula Weight: 254.24
MOL File: 55520-67-7.mol

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5-vinyl-2'-deoxyuridine Property

Melting point:: 106-110 °C (decomp)
Boiling point:: 397.45°C (rough estimate)
Density: 1.2983 (rough estimate)
refractive index: 1.5700 (estimate)
solubility: soluble in DMSO
pka: 9.07±0.10(Predicted)
form: Solid
Appearance: yellowish solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: NUC0003195
Product name: 5-VINYL-2'-DEOXYURIDINE
Purity: 95.00%
Packaging: 5MG
Price: $503.79
Updated: 2021/12/16

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5-vinyl-2'-deoxyuridine Chemical Properties,Usage,Production

Description

VdU (5-Vinyl-2’-deoxyuridine) is a synthetic analog of thymidine that can be used to study de novo DNA synthesis and cell proliferation. It is a potential replacement for BrdU (5-Bromo-2’-deoxyuridine) or EdU (5-Ethynyl-2’-deoxyuridine).

VdU incorporates into replicating DNA during the S-phase of the cell cycle instead of natural thymidine. The resulting vinyl-functionalized DNA can be detected by introducing either a biotin or fluorescent dye group via a cooper-free alkene-tetrazine reaction (also known as Inverse electron demand Diels-Alder ligation or IEDDA) and used for subsequent DNA purification or cell imaging tasks.

Uses

5-Vinyl-2'-deoxyuridine (5-VINYL-DURD), a thymidine analogue, is incorporated into cellular DNA during DNA replication. 5-Vinyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and induces DNA damage leads to apoptosis in human cultured cells[1].

References

[1] Yizhu Li, et al. DNA templated Click Chemistry via 5-vinyl-2'-deoxyuridine and an acridine-tetrazine conjugate induces DNA damage and apoptosis in cancer cells. Life Sci. 2023 Oct 1:330:122000. DOI:10.1016/j.lfs.2023.122000

5-vinyl-2'-deoxyuridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-vinyl-2'-deoxyuridine Suppliers

China 25 United States 2 Global 27

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View Lastest Price from 5-vinyl-2'-deoxyuridine manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: 5-vinyl-2'-deoxyuridine 55520-67-7
Price: US $0.00/mg
Min. Order: 500mg
Purity: >95.00%
Supply Ability: 500mg
Release date: 2024-03-30

55520-67-7, 5-vinyl-2'-deoxyuridineRelated Search:

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5-vinyl-2'-deoxyuridine

2'-Deoxy-5-vinyluridine

2'-Deoxy-5-ethenyluridine

5-vinyldeoxyuridine

5-VINYLDEOXYURIDINE; 2'-DEOXY-5-ETHENYLURIDINE; 5-VINYL-DURD; 2'-DEOXY-5-VINYLURIDINE

5-Vinyl-dUrd

5-Vinyl-2'-deoxyuridine (5-VdU)

Uridine, 2'-deoxy-5-ethenyl-

BrivudineImpurity10

Tylosin Impurity 7

5-Vinyl-2&#8242,-deoxyuridine (5-VdU) (10 mg)

5-Vinyl-2&#8242,-deoxyuridine (5-VdU) (50 mg)

1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-vinylpyrimidine-2,4(1H,3H)-dione

55520-67-7