L 738372
- Product Name
- L 738372
- CAS No.
- 159565-60-3
- Chemical Name
- L 738372
- Synonyms
- 372;L738;L-738;L 738;L 738372
- CBNumber
- CB91315841
- Molecular Formula
- C18H14ClN3O
- Formula Weight
- 323.77626
- MOL File
- 159565-60-3.mol
L 738372 Chemical Properties,Usage,Production
Description
L 738372 is a quinazolinone; a non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Uses
L-738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with an inhibition constant (Ki) of 140 nM against dTTP. When combined with any nucleoside analogs (such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate), L-738372 exhibits synergistic inhibition of RT activity. L-738372 has 2-3 times more inhibitory potency against the azidothymidine-resistant RT (D67N, K70R, T215Y, K219Q) compared to the wild-type RT. L-738372 holds promise for research in the field of HIV virus treatment[1].
IC 50
HIV-1
References
[1] Carroll S S, et al. Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs[J]. Journal of Biological Chemistry, 1994, 269(51): 32351-32357. PMID:7528214
L 738372 Preparation Products And Raw materials
Raw materials
Preparation Products
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