LY 25648

Product Name: LY 25648
CAS No.: 107889-31-6
Chemical Name: LY 25648
Synonyms: LY 25648;LY-256548;Dihydro-3-methyl-5-(4-hydroxy-3,5-ditert-butylbenzylidene)thiazol-4(5H)-one;4-Thiazolidinone, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-3-methyl-
CBNumber: CB91332073
Molecular Formula: C19H27NO2S
Formula Weight: 333.49
MOL File: 107889-31-6.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0001148
Product name: LY-256548
Purity: 95.00%
Packaging: 5MG
Price: $499.55
Updated: 2021/12/16

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LY 25648 Chemical Properties,Usage,Production

Description

LY 25648 is a leukotriene B4 antagonist.

Uses

LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 (HY-N6687)-stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model[1][2].

in vivo

The oral absorption of LY256548 (LY25648) in rats, dogs, and monkeys was 45%, 7%, and 12%, respectively, and the systemic bioavailability was 6%, 0.4%, and 3%, respectively^[1].

IC 50

Cyclooxygenase; 5-LOX; PLA2; LTB₄

References

[1] Ruterbories KJ, et al. Pharmacokinetics of a novel butylated hydroxytoluene-thiazolidinone CNS antiischemic agent LY256548 in rats, mice, dogs, and monkeys. Drug Metab Dispos. 1990 Sep-Oct;18(5):674-9. PMID:1981719
[2] Panetta JA, et al. The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2. DOI:10.1007/BF01972804

LY 25648 Preparation Products And Raw materials

Raw materials

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LY 25648 Suppliers

China 1 United States 2 Global 3

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29357
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19961
Advantage: 58

107889-31-6, LY 25648Related Search:

LY 25648

Dihydro-3-methyl-5-(4-hydroxy-3,5-ditert-butylbenzylidene)thiazol-4(5H)-one

LY-256548

4-Thiazolidinone, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-3-methyl-

107889-31-6