cosalane

Product Name: cosalane
CAS No.: 154212-56-3
Chemical Name: cosalane
Synonyms: cosalane;NSC-658586;NSC 658586;Benzoic acid, 3,3'-[4-(3β,5α)-cholestan-3-yl-1-butenylidene]bis[5-chloro-6-hydroxy-;5-{4-[(1R,3aS,3bR,5aS,7S,9aS,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-1-(3-carboxy-5-chloro-4-hydroxyphenyl)but-1-en-1-yl}-3-chloro-2-hydroxybenzoic acid
CBNumber: CB91338121
Molecular Formula: C45H60Cl2O6
Formula Weight: 767.86
MOL File: 154212-56-3.mol

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cosalane Property

Boiling point:: 797.4±60.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
pka: 2.07±0.14(Predicted)
form: Solid
color: White to off-white
Water Solubility: 1.4ug/L(temperature not stated)

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Hazard and Precautionary Statements (GHS)

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cosalane Chemical Properties,Usage,Production

Uses

Cosalane (NSC 658586) is a potent inhibitor of HIV replication. Cosalane has an intrinsic ability to block human and murine CCR7 function in vitro in response to both of its natural ligands, CCL19 and CCL21, with the IC50 of 0.207/2.66 μM in human for CCL19/CCL21 and 0.193/1.98 μM in murine, respectively[1][2].

IC 50

Human CCR7; Murine CCR7

References

[1] Kenneth A Fowler, et al. The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models. Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074. DOI:10.1016/j.bbmt.2019.01.022
[2] Emily A Hull-Ryde, et al. Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen. SLAS Discov. 2018 Dec;23(10):1083-1091. DOI:10.1177/2472555218780917

cosalane Preparation Products And Raw materials

Raw materials

Preparation Products

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cosalane Suppliers

China 5 United States 1 Global 6

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Guangzhou Boshao Biotechnology Co., Ltd.

Tel: 18665625935
Country: CHINA
ProdList: 194
Advantage: 58

154212-56-3, cosalaneRelated Search:

3-CHLORO-5-METHYL-BENZOIC ACID 4,4'-dihydroxy-3-(hydroxymethyl)diphenylmethane 4,4'-dihydroxy-3,3'-di-(hydroxymethyl)diphenylmethane cosalane 5,5'-Methylenedisalicylic acid

cosalane

Benzoic acid, 3,3'-[4-(3β,5α)-cholestan-3-yl-1-butenylidene]bis[5-chloro-6-hydroxy-

NSC 658586

NSC-658586

5-{4-[(1R,3aS,3bR,5aS,7S,9aS,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-1-(3-carboxy-5-chloro-4-hydroxyphenyl)but-1-en-1-yl}-3-chloro-2-hydroxybenzoic acid

154212-56-3

C45H60Cl2O6