PD 132301-2

Product Name: PD 132301-2
CAS No.: 133825-81-7
Chemical Name: PD 132301-2
Synonyms: ATR-101 HCl;PD 132301-2;Nevanimibe);ATR-101 (PD-132301;ATR101 hydrochloride;PD-132301 hydrochloride;Nevanimibe hydrochloride;Nevanimibe hydrochloride, 10 mM in DMSO;Urea, N-[2,6-bis(1-methylethyl)phenyl]-N′-[[1-[4-(dimethylamino)phenyl]cyclopentyl]methyl]-, hydrochloride (1:1);cancer,O-acyltransferase,acyl-CoA:cholesterol acyltransferase,acyl-coenzyme,PD-132301,Diglyceride acyltransferase,orally,adrenocortical,Acyltransferase,A:cholesterol,mono- acylglycerol acyltransferase,Nevanimibe hydrochloride,inhibit,PD 132301,Apoptosis,Nevanimibe,ATR 101,PD132301,ATR-101,Diacylglycerol acyltransferase,active,ATR101,Inhibitor
CBNumber: CB91338181
Molecular Formula: C27H40ClN3O
Formula Weight: 458.09
MOL File: 133825-81-7.mol

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PD 132301-2 Property

storage temp.: 4°C, away from moisture
solubility: DMSO : 41.67 mg/mL (90.97 mM; Need ultrasonic)| (insoluble)
form: Solid
color: White to off-white
Water Solubility: Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2802
Product name: ATR-101
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $107
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2802
Product name: ATR-101
Purity: ≥98%(HPLC)
Packaging: 25MG
Price: $440
Updated: 2024/03/01

Axon Medchem

Product number: Axon2960
Product name: ATR-101-PD132301-2|Nevanimibehydrochloride
Purity: 98%
Packaging: 50mg
Price: $599.5
Updated: 2021/12/16

ChemScene

Product number: CS-0018786
Product name: Nevanimibehydrochloride
Purity: 99.77%
Packaging: 50mg
Price: $1400
Updated: 2021/12/16

ChemScene

Product number: CS-0018786
Product name: Nevanimibehydrochloride
Purity: 99.77%
Packaging: 100mg
Price: $2200
Updated: 2021/12/16

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PD 132301-2 Chemical Properties,Usage,Production

Uses

Nevanimibe Hydrochloride can be used for combinatory treatment strategies of cancer based on RNA polymerase I inhibition.

Biological Activity

ATR-101 (PD 132301-02; Nevanimibe HCl) is an orally active, potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT1, SOAT1) inhibtior (IC50 = 52 nM; intestinal microsome from cholesterol-fed rabbits) th at reduces plasma cholesterol in both acute (by 77%; 50 mg/kg po.) and chronic (by 80%; 10 mg/kg po.) cholesterol-fed r at models. In addition, ATR-101 is reported to exhibit therapeutic efficacy against adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH), and Cushingμs syndrome (CS).

PD 132301-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 132301-2 Suppliers

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133825-81-7, PD 132301-2Related Search:

Beryllium

PD 132301-2

ATR-101 HCl

Nevanimibe hydrochloride

ATR-101 (PD-132301

Nevanimibe)

ATR101 hydrochloride

PD-132301 hydrochloride

cancer,O-acyltransferase,acyl-CoA:cholesterol acyltransferase,acyl-coenzyme,PD-132301,Diglyceride acyltransferase,orally,adrenocortical,Acyltransferase,A:cholesterol,mono- acylglycerol acyltransferase,Nevanimibe hydrochloride,inhibit,PD 132301,Apoptosis,Nevanimibe,ATR 101,PD132301,ATR-101,Diacylglycerol acyltransferase,active,ATR101,Inhibitor

Urea, N-[2,6-bis(1-methylethyl)phenyl]-N′-[[1-[4-(dimethylamino)phenyl]cyclopentyl]methyl]-, hydrochloride (1:1)

Nevanimibe hydrochloride, 10 mM in DMSO

133825-81-7