RP 54745

Product Name: RP 54745
CAS No.: 135330-08-4
Chemical Name: RP 54745
Synonyms: RP 54745;RP-54745, 10 mM in DMSO;inhibit,RP-54745,RP 54745,Inhibitor,RP54745,Interleukin Related;4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one;4-Chloro-5-(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-3H-1,2-dithiol-3-one;3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-
CBNumber: CB91338303
Molecular Formula: C13H12ClNOS2
Formula Weight: 297.82
MOL File: 135330-08-4.mol

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RP 54745 Property

Boiling point:: 411.4±55.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : 62.5 mg/mL (209.86 mM);Water : < 0.1 mg/mL (insoluble)
pka: -2.57±0.40(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6750
Product name: RP-54745
Purity: 99.93%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 8982CA
Product name: 4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one
Packaging: 50mg
Price: $205
Updated: 2021/12/16

ChemScene

Product number: CS-6750
Product name: RP-54745
Purity: 99.93%
Packaging: 5mg
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 8982CA
Product name: 4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one
Packaging: 100mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-6750
Product name: RP-54745
Purity: 99.93%
Packaging: 10mg
Price: $408
Updated: 2021/12/16

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RP 54745 Chemical Properties,Usage,Production

Uses

RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.

in vivo

RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745^[2].

IC 50

IL-1

References

[1] Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions. 1992 May;36(1-2):119-26. DOI:10.1007/BF01991239
[2] Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992 May;36(1-2):127-35. DOI:10.1007/BF01991240

RP 54745 Preparation Products And Raw materials

Raw materials

Preparation Products

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RP 54745 Suppliers

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135330-08-4, RP 54745Related Search:

RP 54745

4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one

3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-

inhibit,RP-54745,RP 54745,Inhibitor,RP54745,Interleukin Related

4-Chloro-5-(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-3H-1,2-dithiol-3-one

RP-54745, 10 mM in DMSO

135330-08-4