5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone
- Product Name
- 5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone
- CAS No.
- 150045-18-4
- Chemical Name
- 5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone
- Synonyms
- MS-444;BE-34776;MS 444,MS444;5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone;Naphtho[2,3-c]furan-4(9H)-one, 5,8-dihydroxy-3-methyl-
- CBNumber
- CB91339067
- Molecular Formula
- C13H10O4
- Formula Weight
- 230.22
- MOL File
- 150045-18-4.mol
5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone Property
- Boiling point:
- 448.7±45.0 °C(Predicted)
- Density
- 1.452±0.06 g/cm3(Predicted)
- pka
- 8.14±0.20(Predicted)
- form
- Solid
- color
- Light yellow to brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0019951
- Product name
- MS-444
- Purity
- 99.13%
- Packaging
- 5mg
- Price
- $450
- Updated
- 2021/12/16
5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone Chemical Properties,Usage,Production
Uses
MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM.
in vivo
To test the effects of MS-444 on CRC cell growth in vivo, mice bearing HCT116 cell xenografts receive IP injections of MS-444 (25 mg/kg bw) or vehicle every 48 hr. Over the experiment course, mice do not display any adverse effects and maintained similar weights. Anti-tumor effects of MS-444 are observed with approximately 1.7-fold reduction in tumor size. Mice treated with MS-444 show a marked 2- to 3-fold decrease in microvessel density (MVD), indicating the anti-angiogenic potential of MS-444[2].
References
[1] Satoshi Nakanishi. et al. MS-444, a new inhibitor of myosin light chain kinase from Micromonosporasp.KY7123. The Journal Of Antibiotics. 1995,48(9):948-951. DOI:10.7164/antibiotics.48.948
[2] Fernando F. Blanco.et al, Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. Oncotarget. 2016 Nov 8; 7(45): 74043-74058. DOI:10.18632/oncotarget.12189
5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone Preparation Products And Raw materials
Raw materials
Preparation Products
5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone Suppliers
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