2-bromolysergic acid diethylamide

2-bromolysergic acid diethylamide Property

Melting point:

120-127°

alpha 

D20 +15° (c = 0.5 in pyridine); D20 +53° (c = 0.5 in chloroform)

Density 

1.3040 (rough estimate)

refractive index 

1.6770 (estimate)

solubility 

DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml

form 

Solid

Boiling point:

580.7±50.0 °C(Predicted)

pka

15.65±0.40(Predicted)

color 

Off-white to light yellow

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

2-bromolysergic acid diethylamide Chemical Properties,Usage,Production

Uses

2-Bromo-LSD (BOL-148; Bromolysergide) is a Dopamine Receptor antagonist that directly affects dopamine neurons in the substantia nigra neostriatum. 2-Bromo-LSD increases the hydroxylation of tyrosine in striatum and antagonizes the decrease of Apomorphine-induced DOPA accumulation. 2-Bromo-LSD also blocks the 5-HT Receptor mediated DOPA formation[1].

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: ddation of the arteries or veins. Many lysergic acid derivatives have central nervous system effects. When heated to decomposition it emits very toxic fumes such as Brand NOx. See other lysergic acid derivatives.

in vivo

References

[1] Persson SA. The effect of LSD and 2-bromo LSD on the striatal DOPA accumulation after decarboxylase inhibition in rats. Eur J Pharmacol. 1977 May 1;43(1):73-83. DOI:10.1016/0014-2999(77)90162-5
[2] PAUL CARVEY . LSD and other related hallucinogens elicit myoclonic jumping behavior in the guinea pig[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 1989, 13 1: Pages 199-210. DOI: 10.1016/0278-5846(89)90017-1
[3] WACHEŁKO O, NOWAK K, TUSIEWICZ K, et al. A highly sensitive UHPLC-MS/MS method for determining 15 designer LSD analogs in biological samples with application to stability studies†[J]. Analyst, 2024, 2: 290-308. DOI: 10.1039/d4an01361a