R 82913

Product Name: R 82913
CAS No.: 126347-69-1
Chemical Name: R 82913
Synonyms: R 82913;9-Cl-Tibo;NSC 637653;TIBO-R82913;TIBO-R-82913;9-Chloro TIBO;R82913. 9-Cmbib;NSC 637653, 9-Cl-Tibo;4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-9-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione;(+)-(S)-4,5,6,7-tetrahydro-9-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo<4,5,1-jk><1,4>benzodiazepine-2(1H)-thione
CBNumber: CB91347349
Molecular Formula: C16H20ClN3S
Formula Weight: 321.87
MOL File: 126347-69-1.mol

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R 82913 Property

Boiling point:: 429.7±55.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
pka: 11.35±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0015496
Product name: R-82913
Purity: 95.00%
Packaging: 5MG
Price: $495.62
Updated: 2021/12/16

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R 82913 Chemical Properties,Usage,Production

Uses

R82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis). R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC50 value of of 0.15 μM[1][2].

References

[1] White EL, et al. A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res. 1991 Oct;16(3):257-66. DOI:10.1016/0166-3542(91)90005-c
[2] Larder BA. 3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother. 1992 Dec;36(12):2664-9. DOI:10.1128/AAC.36.12.2664

R 82913 Preparation Products And Raw materials

Raw materials

Preparation Products

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R 82913 Suppliers

China 1 United States 2 Global 3

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29357
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19961
Advantage: 58

126347-69-1, R 82913Related Search:

R 82913

[5S,(+)]-4,5,6,7-Tetrahydro-9-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione

4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-9-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione

9-Chloro TIBO

TIBO-R82913

TIBO-R-82913

(+)-(S)-4,5,6,7-tetrahydro-9-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo<4,5,1-jk><1,4>benzodiazepine-2(1H)-thione

9-Cl-Tibo

NSC 637653

R82913. 9-Cmbib

NSC 637653, 9-Cl-Tibo

Imidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione, 9-chloro-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-buten-1-yl)-, (5S)-

126347-69-1