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E 3330

Product Name
E 3330
CAS No.
136164-66-4
Chemical Name
E 3330
Synonyms
E 3330;CS-1756;APX3330;APX 3330;E 3330;E-3330;E3330 (APX-3330);(2E)-3-(5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl))-2-nonyl-2-propenoic acid;(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid;Undecanoic acid, 2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-, (2E)-;(2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid E3330
CBNumber
CB91355838
Molecular Formula
C21H30O6
Formula Weight
378.46
MOL File
136164-66-4.mol
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E 3330 Property

Melting point:
56-57 °C
Boiling point:
542.2±50.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
powder
pka
4.29±0.19(Predicted)
color 
red to orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E8534
Product name
E3330
Purity
≥98% (HPLC)
Packaging
5mg
Price
$354
Updated
2024/03/01
Sigma-Aldrich
Product number
E8534
Product name
E3330
Purity
≥98% (HPLC)
Packaging
25mg
Price
$1060
Updated
2024/03/01
Usbiological
Product number
447762
Product name
E 3330
Packaging
5mg
Price
$432
Updated
2021/12/16
TRC
Product number
E101500
Product name
E3330
Packaging
5mg
Price
$135
Updated
2021/12/16
ChemScene
Product number
CS-0015424
Product name
E3330
Purity
98.01%
Packaging
5mg
Price
$135
Updated
2021/12/16
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E 3330 Chemical Properties,Usage,Production

Uses

E 3330 is a potent and selective APE1 inhibitor used in the treatment for age related macular degeneration.

Uses

E3330 has been used in the inhibition of endothelial cancer cells and apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1).

Biological Activity

ap endonuclease 1 (ape1) is a dual-function protein, which contains a redox domain and a dna repair domain. ape1 is overexpressed in numerous solid cancers, including prostate and bladder cancers, non-small cell lung cancers, gliomas, medulloblastomas and primitive neurectodermal tumors, osteosarcomas, and germ cell tumors. e3330 is a small molecule inhibitor of redox activity of ape1 protein.

Biochem/physiol Actions

E3330 is a specific inhibitor of AP endonuclease 1 redox domain. E3330 inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. AP endonuclease 1 (APE1; also known as REF-1) is a multifunctional protein with dual functions in DNA repair and redox regulation of transcription factors. It is involved in apurinic/apyrimidinic endonuclease DNA base excision repair activity, in proofreading exonuclease activity, and in modulating DNA binding activity of several transcription factors including NF-κB, Egr-1, p53, AP-1, CREB, HIF-α, and members of the Pax family. APE1 is overexpressed in several human cancers, and disruption of APE1 function has detrimental effects on cancer cell viability. E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration.

in vitro

e3330 significantly reduces the growth of human pancreatic cancer cells in vitro. this phenomenon was further confirmed by a small interfering rna experiment to knockdown ape1 expression in pancreatic cancer cells. furthermore, the growth-inhibitory effects of e3330 are accentuated by hypoxia, and this is accompanied by striking inhibition in the dna binding ability of hypoxia-inducible factor-1α [1].

in vivo

oral pretreatment with e3330 attenuated the elevation of plasma tumor necrosis factor activity and protected micefrom liver injury. furthermore, e3330 inhibited the production of tumor necrosis factor from cultured propionibacterium acnes-elicited murine peritoneal macrophages on stimulation with lipopolysaccharide in vitro [2].

References

[1] gang-ming zou and anirban maitra. small-molecule inhibitor of the ap endonuclease 1/ref-1 e3330 inhibits pancreatic cancer cell growth and migration. mol cancer ther. 2008 jul; 7(7): 2012–2021.
[2] nagakawa j, hishinuma i, miyamoto k, hirota k, abe s, yamanaka t, katayama k, yamatsu i. protective effects of (2e)-3-[5-(2,3-dimethoxy-6-methyl-1,4- benzoquinoyl)]-2-nonyl-2-propenoic acid on endotoxin-mediated hepatitis in mice. j pharmacol exp ther. 1992 jul;262(1):145-50.

E 3330 Preparation Products And Raw materials

Raw materials

Preparation Products

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E 3330 Suppliers

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136164-66-4, E 3330Related Search:


  • (2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid E3330
  • (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid
  • E 3330
  • CS-1756
  • E 3330;E-3330
  • APX 3330
  • APX3330
  • Undecanoic acid, 2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-, (2E)-
  • E3330 (APX-3330)
  • pancreatic cancer,TNF-α,E3330,REF-1,NF-κB,HIFs,Inhibitor,HIF-PH,Nuclear factor-kappaB,APX-3330,APE1,APX 3330,NSCLC cells,neuroprotective,E 3330,APX3330,endonuclease,VEGFR,EPCs,AP-1,HUVECs,Nuclear factor-κB,Reactive Oxygen Species,DNA-binding,Activator Protein 1,DNA/RNA Synthesis,Hypoxia-inducible factors,orally,PANC1,HIF/HIF Prolyl-Hydroxylase,E-3330,anticancer,H1975,PCECs,inhibit,IL-8,Vascular endothelial growth factor receptor
  • (2E)-3-(5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl))-2-nonyl-2-propenoic acid
  • 136164-66-4