1-Oxa-3,8-diazaspiro(4.5)decan 2-one

Product Name: 1-Oxa-3,8-diazaspiro(4.5)decan 2-one
CAS No.: 5052-95-9
Chemical Name: 1-Oxa-3,8-diazaspiro(4.5)decan 2-one
Synonyms: 1-Oxa-3,8-diazaspiro(4.5)decan 2-one;1-oxy-3,8-diazaspiro[4.5]decylalkane-2-one;1-oxa-3,8-diazaspiro[4.5]decan-2-one - [X23979];1-oxa-3,8-diazaspiro[4.5]decan-2-one(SALTDATA: HCl)
CBNumber: CB91357458
Molecular Formula: C7H12N2O2
Formula Weight: 156.18
MOL File: 5052-95-9.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0304716
Product name: 1-OXA-3,8-DIAZASPIRO[4.5]DECAN-2-ONE
Purity: 95.00%
Packaging: 5MG
Price: $495.07
Updated: 2021/12/16

AK Scientific

Product number: 6962AB
Product name: 1-Oxa-3,8-diazaspiro[4.5]decan-2-one
Packaging: 1g
Price: $821.6
Updated: 2021/12/16

Labseeker

Product number: SC-94986
Product name: 1-Oxa-3,8-diazaspiro[4.5]decan-2-one
Purity: 95
Packaging: 5g
Price: $1617
Updated: 2021/12/16

Chemenu

Product number: CM139344
Product name: 1-Oxa-3,8-diaza-spiro[4.5]decan-2-one
Purity: 95%
Packaging: 1g
Price: $505
Updated: 2021/12/16

Crysdot

Product number: CD11114450
Product name: 1-Oxa-3,8-diazaspiro[4.5]decan-2-one
Purity: 95+%
Packaging: 1g
Price: $540
Updated: 2021/12/16

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1-Oxa-3,8-diazaspiro(4.5)decan 2-one Chemical Properties,Usage,Production

Synthesis

5053-14-5

5052-95-9

General procedure for the synthesis of 1-oxo-3,8-diazaspiro[4,5]decan-2-one from 8-benzyl-1-oxo-3,8-diazaspiro[4,5]decan-2-one: 8-benzyl-1-oxo-3,8-diazaspiro[4,5]decan-2-one (170 mg, 0.69 mmol) was dissolved in methanol (20 mL), ammonium formate (261 mg) and 10% Pd/C (89 mg). The reaction mixture was stirred and refluxed for 1.5 h at room temperature. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the solvent was removed under vacuum. The residue was dissolved in methanol and the solution was allowed to pass through a SCX column pre-washed with methanol and eluted with a methanol solution of 2N ammonia to afford 1-oxo-3,8-diazaspiro[4,5]decan-2-one (80 mg, 74% yield). Mass spectrum (electrospray ionization) (m/z): 157.0 [M+H]+.

References

[1] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 4, p. 340 - 345
[2] Patent: WO2016/42452, 2016, A1. Location in patent: Page/Page column 202
[3] Chimica Therapeutica, 1969, vol. 4, p. 185 - 194
[4] Journal of Medicinal Chemistry, 1981, vol. 24, # 11, p. 1320 - 1328
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 3, p. 1078 - 1101

1-Oxa-3,8-diazaspiro(4.5)decan 2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Oxa-3,8-diazaspiro(4.5)decan 2-one Suppliers

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