CI 972

Product Name: CI 972
CAS No.: 115787-68-3
Chemical Name: CI 972
Synonyms: CI 972;CI 972 (anhydrous);2,6-Diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo(3,2-D)pyrimidin-4-one
CBNumber: CB91365725
Molecular Formula: C11H12ClN5OS
Formula Weight: 297.76
MOL File: 115787-68-3.mol

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CI 972 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0001131
Product name: CI-972
Purity: 95.00%
Packaging: 5MG
Price: $499.4
Updated: 2021/12/16

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CI 972 Chemical Properties,Usage,Production

Uses

CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2].

in vivo

CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats^[1].

References

[1] Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. DOI:10.1007/978-1-4899-2638-8_8
[2] Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8. DOI:10.1016/0006-291x(91)91042-b

CI 972 Preparation Products And Raw materials

Raw materials

Preparation Products

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CI 972 Suppliers

China 4 United States 5 Global 9

BOC Sciences

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Biosynth Biological Technology (Suzhou) Co Ltd

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Adooq Bioscience LLC

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TargetMol Chemicals Inc.

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115787-68-3, CI 972Related Search:

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) 1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE 9-deaza-9-(3-thienylmethyl)guanine CI 972

CI 972

CI 972 (anhydrous)

2,6-Diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo(3,2-D)pyrimidin-4-one

115787-68-3