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Methotrexate disodium salt

Product Name
Methotrexate disodium salt
CAS No.
7413-34-5
Chemical Name
Methotrexate disodium salt
Synonyms
mtxdisodium;METHOTREXATUM;l-(+)-isodiumsal;amethopterinsodium;sodium methotrexate;disodiummethotrexate;METHOTREXATE DISODIUM;Methotrexatedisodiumsal;METHOTREXATE DISODIUM SALT;D3-Methotrexate Disodium Salt
CBNumber
CB9136836
Molecular Formula
C20H23N8NaO5
Formula Weight
478.44
MOL File
7413-34-5.mol
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Methotrexate disodium salt Property

Boiling point:
823℃
RTECS 
MA1232000
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Water (Slightly)
form 
Powder
color 
Light yellow to yellow
Water Solubility 
Soluble in water
Sensitive 
Hygroscopic
InChIKey
MSDCZRQHAGWZSH-NVZXTOETNA-N
SMILES
NC1=NC(N)=NC2N=CC(CN(C3C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=3)C)=NC1=2.[NaH] |&1:19,r|
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Safety

HazardClass 
6.1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3779
Product name
Methotrexate disodium salt
Purity
≥98% (HPLC)
Packaging
50mg
Price
$81.2
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3779
Product name
Methotrexate disodium salt
Purity
≥98% (HPLC)
Packaging
250mg
Price
$328
Updated
2025/07/31
TRC
Product number
M260753
Product name
MethotrexateDisodiumSalt
Packaging
25mg
Price
$50
Updated
2021/12/16
TRC
Product number
M260753
Product name
MethotrexateDisodiumSalt
Packaging
50mg
Price
$70
Updated
2021/12/16
AK Scientific
Product number
S509
Product name
Methotrexatedisodiumsalt
Packaging
25mg
Price
$49
Updated
2021/12/16
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Methotrexate disodium salt Chemical Properties,Usage,Production

Uses

Inhibits the metabolism of folic acid

Definition

ChEBI: Methotrexate disodium is an organic sodium salt that is the disodium salt of methotrexate. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It contains a methotrexate(2-).

Biological Activity

Methotrexate disodium salt is a potent is a folic acid antagonist th at is used as an antineoplastic and antirheumatic drug. Methotrexate disodium salt is a potent inhibitor of dihydrofolate reductase.

in vivo

Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2].
Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4].

IC 50

Traditional Cytotoxic Agents

Methotrexate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Methotrexate disodium salt Suppliers

China 219 Finland 2 Germany 1 India 3 Japan 2 United States 12 Global 239
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from Methotrexate disodium salt manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Methotrexate disodium salt 7413-34-5
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%min
Supply Ability
300/month
Release date
2021-06-03
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Methotrexate disodium salt 7413-34-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-04-16
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Methotrexate Disodium 7413-34-5
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-08-05

7413-34-5, Methotrexate disodium saltRelated Search:

Methotrexate IMpurity C Pemetrexed Disodium 1,1,3-Tribromoacetone Etoposide Methotrexate METHOTREXATE, DISODIUM SALT, [3',5',7-3H(N)]- METHOTREXATE DISODIUM SALT, [L-GLUTAMIC (1-14C)]

  • Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate
  • sodium methotrexate
  • L-Glutamic acid, N-4-(2,4-diamino-6-pteridinyl)methylmethylaminobenzoyl-, disodium salt
  • METHOTREXATUM
  • 2-[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]aminopentanedioic acid
  • (+)-N-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt
  • (+)-N-[4-[[(2,4-Diaminopteridine-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt
  • 4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt
  • amethopterinsodium
  • disodiummethotrexate
  • l-(+)-isodiumsal
  • mtxdisodium
  • METHOTREXATE DISODIUM
  • METHOTREXATE DISODIUM SALT
  • Methotrexate Disodium Salt Solution
  • L-GlutaMic acid,N-[4-[[(2,4-diaMino-6-pteridinyl)Methyl]MethylaMino]benzoyl]-, sodiuM salt(1:2)
  • Methotrexatedisodiumsal
  • Methotrexate disodium salt USP/EP/BP
  • Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate
  • N-[4-Cyano-3-(trifluoromethyl)|pheny/l-3-[(4-fluoropheny)thio)-2-hydroxy-2-methylpropionamide'
  • sodium (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamate
  • D3-Methotrexate Disodium Salt
  • 3-Hydroxyoctadecanoylcarnitine
  • 7413-34-5
  • C20H20N8Na2O5
  • C20H20N8O52Na
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  • API
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