ChemicalBook > CAS DataBase List > siomycin A

siomycin A

Product Name: siomycin A
CAS No.: 12656-09-6
Chemical Name: siomycin A
Synonyms: siomycin A;Salomycin A;Mutabilycin;Mutabillicin;Antibiotic 6741-21;AKFVOKPQHFBYCA-OFENGFFDSA-N;Mutabilycin, SporangioMycin, 6741-21, Mutabillicin;Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexa...
CBNumber: CB91371285
Molecular Formula: C71H81N19O18S5
Formula Weight: 1648.84
MOL File: 12656-09-6.mol

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siomycin A Property

Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: complete10 mg/ml, clear, colorless to faintly yellow
form: White solid.
pka: 10.43±0.46(Predicted)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15378
Product name: Siomycin A
Purity: ≥95%
Packaging: 500μg
Price: $396
Updated: 2024/03/01

TRC

Product number: S497053
Product name: Siomycin A
Packaging: 1000μg
Price: $545
Updated: 2021/12/16

Usbiological

Product number: S1013-86W
Product name: Siomycin A
Packaging: 500ug
Price: $582
Updated: 2021/12/16

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siomycin A Chemical Properties,Usage,Production

Uses

Siomycin A is an antibiotic that inhibits FoxM1.

Uses

Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Siomycin is a potent inhibitor of the oncogenic transcription factor, FoxM1. The reduced transcription activity is reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes, Cdc25B, survivin and CENPB. In vitro, siomycin inhibits FoxM1-induced cell growth on soft agar and selectively kill transformed but not normal cells.

in vivo

Siomycin A (1 μM; subcutaneous injection; for 4 weeks; male Balb/c nude mice) pretreatment decreases tumour growth in an in vivo mouse model^[2].

Animal Model:	Four- to five-week old male Balb/c nude mice with IOMM-LEE cells^[2]
Dosage:	1 μM-pretreated IOMM-Lee cells
Administration:	Subcutaneous injection; for 4 weeks
Result:	Decreased tumour growth in an in vivo mouse model.

siomycin A Preparation Products And Raw materials

Raw materials

Preparation Products

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siomycin A Suppliers

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12656-09-6, siomycin ARelated Search:

Clindamycin Acetylspiramycin Penicillin G Gentamicin Clarithromycin Azithromycin

Antibiotic 6741-21

Mutabillicin

Mutabilycin

AKFVOKPQHFBYCA-OFENGFFDSA-N

siomycin A

Mutabilycin, SporangioMycin, 6741-21, Mutabillicin

Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexa...

Salomycin A

12656-09-6

C71H81N19O18S5