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3-deoxyvasicine

Product Name
3-deoxyvasicine
CAS No.
495-59-0
Chemical Name
3-deoxyvasicine
Synonyms
3-deoxyvasicine;Pyrrolo[2,1-b]quinazoline, 1,2,3,9-tetrahydro-
CBNumber
CB91374837
Molecular Formula
C11H12N2
Formula Weight
172.23
MOL File
495-59-0.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
T304163
Product name
1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline
Packaging
100mg
Price
$265
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0303628
Product name
1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLINE
Purity
95.00%
Packaging
5MG
Price
$503.39
Updated
2021/12/16
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3-deoxyvasicine Chemical Properties,Usage,Production

Uses

Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research[1].

Definition

ChEBI: Deoxypeganine is a member of quinazolines.

in vivo

Desoxypeganine (10-30 mg/kg, gavage, once daily for 16 days) reduced ethanol intake and ethanol preference dose-dependently[1].

Animal Model:Female Alko alcohol (AA) rats (Thirty eight adult)[1]
Dosage:10, 20, 30 mg/kg
Administration:Gavage, once daily in a volume of 10 ml/kg at 6:00 pm, for 16 days
Result:Abolished ethanol preference.

IC 50

BChE: 2 μM (IC50); AChE: 17 μM (IC50); MAO-A: 2 μM (IC50)

References

[1] Doetkotte R, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. DOI:10.1016/j.ejphar.2005.08.038
[2] Zheng XY, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res. 2009 Sep;32(9):1245-51. DOI:10.1007/s12272-009-1910-x

3-deoxyvasicine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-deoxyvasicine Suppliers

CHINA 3 United States 1 Global 4
Shanghai Taopu Industrial Co., LTD
Tel
159-00573766 18018507602
Email
394643792@qq.com
Country
China
ProdList
4328
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-025-66113011 18626450290
Email
cb5@aikonchem.com
Country
China
ProdList
10358
Advantage
58
Guangzhou Aoz Biotechnology Co., Ltd.
Tel
18022383332
Country
CHINA
ProdList
0
Advantage
58

495-59-0, 3-deoxyvasicineRelated Search:


  • 3-deoxyvasicine
  • Pyrrolo[2,1-b]quinazoline, 1,2,3,9-tetrahydro-
  • 495-59-0