SR 11237

Product Name: SR 11237
CAS No.: 146670-40-8
Chemical Name: SR 11237
Synonyms: BMS649;SR 11237;BMS 188649;SR11237, 10 mM in DMSO;4-(2-(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acid;4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacid;Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-;Retinoid X receptors,bone,BMS 649,transactivate,BMS649,Retinoic acid receptors,reporter,ossification,RAR/RXR,inhibit,Inhibitor,RXR/RXR,BMS-649,SR11237,homodimers,gene,SR-11237
CBNumber: CB91379089
Molecular Formula: C24H28O4
Formula Weight: 380.48
MOL File: 146670-40-8.mol

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SR 11237 Property

storage temp.: Store at -20°C
solubility: DMSO: >28mg/mL (warmed)
form: powder
color: white to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S8951
Product name: SR11237
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $137
Updated: 2025/07/31

Sigma-Aldrich

Product number: S8951
Product name: SR11237
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $530
Updated: 2025/07/31

Tocris

Product number: 3411
Product name: SR11237
Purity: ≥98%(HPLC)
Packaging: 50
Price: $852
Updated: 2021/12/16

Tocris

Product number: 3411
Product name: SR11237
Purity: ≥98%(HPLC)
Packaging: 10
Price: $207
Updated: 2021/12/16

TRC

Product number: S684463
Product name: SR11237
Packaging: 25mg
Price: $310
Updated: 2021/12/16

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SR 11237 Chemical Properties,Usage,Production

Uses

SR 11237 is a pan RXR agonist with without RAR activity. It is used in treatment of neurodegenerative diseases.

Biological Activity

Pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.

in vivo

SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate^[2].

Animal Model:	Sprague-Dawley rats^[2]
Dosage:	25 mg/kg
Administration:	I.p.; daily from post-natal days 5 to 15
Result:	Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis.

storage

Store at -20°C

SR 11237 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 11237 Suppliers

China 55 South Korea 1 United Kingdom 1 United States 7 Global 64

Tocris Bioscience

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Email: customerservice@tocris.co.uk
Country: United Kingdom
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146670-40-8, SR 11237Related Search:

SR 11237

4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacid

4-(2-(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acid

BMS 188649

BMS649

Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-

Retinoid X receptors,bone,BMS 649,transactivate,BMS649,Retinoic acid receptors,reporter,ossification,RAR/RXR,inhibit,Inhibitor,RXR/RXR,BMS-649,SR11237,homodimers,gene,SR-11237

SR11237, 10 mM in DMSO

146670-40-8