(melle-4)cyclosporin
- Product Name
- (melle-4)cyclosporin
- CAS No.
- 143205-42-9
- Chemical Name
- (melle-4)cyclosporin
- Synonyms
- NIM811;Sdz nim811;Sdz-nim-811;Sdz nim 811;(melle-4)cyclosporin;Cyclosporin A, 9-(N-methyl-L-Isoleu);9-(N-Methyl-L-isoleucine)cyclosporin a;Cyclosporin A, 9-(N-methyl-L-isoleucine)-
- CBNumber
- CB91398215
- Molecular Formula
- C62H111N11O12
- Formula Weight
- 1202.64
- MOL File
- 143205-42-9.mol
(melle-4)cyclosporin Property
- Boiling point:
- 1293.6±65.0 °C(Predicted)
- Density
- 1.018±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (83.15 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 13.32±0.70(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-8062
- Product name
- NIM811
- Purity
- 98.82%
- Packaging
- 1mg
- Price
- $336
- Updated
- 2021/12/16
- Product number
- CS-8062
- Product name
- NIM811
- Purity
- 98.82%
- Packaging
- 5mg
- Price
- $1188
- Updated
- 2021/12/16
(melle-4)cyclosporin Chemical Properties,Usage,Production
Uses
NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) [1][2].
in vivo
NIM811 prevents mitochondrial depolarization thereby attenuates liver injury, stimulates regeneration and improves liver function and survival[3].
References
[1] Ma S, et al. NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha IFN. Antimicrob Agents Chemother. 2006 Sep;50(9):2976-82. DOI:10.1128/AAC.00310-06
[2] Waldmeier PC, et al. Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol. 2002 Jul;62(1):22-9. DOI:10.1124/mol.62.1.22
[3] Rehman H, et al. NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liverregeneration after massive hepatectomy. Transplantation. 2011 Feb 27;91(4):406-12. DOI:10.1097/TP.0b013e318204bdb2
(melle-4)cyclosporin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (melle-4)cyclosporin manufacturers
- Product
- NIM811 143205-42-9
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19