6-Hydroxy-2(1H)-3,4-dihydroquinolinone

Product Name: 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
CAS No.: 54197-66-9
Chemical Name: 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
Synonyms: 6-HYDROXY-3,4-DIHYDROQUINOLIN-2(1H)-ONE;6-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE;Q-2;6-HQ;in-2(1H)-one;AURORA KA-4814;6-Hydroxy-2-oxo-1;Cilostazol USP RC A;4-tetrahydroquinoline;Brexpiprazole Impurity 72
CBNumber: CB9143232
Molecular Formula: C9H9NO2
Formula Weight: 163.17
MOL File: 54197-66-9.mol

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6-Hydroxy-2(1H)-3,4-dihydroquinolinone Property

Melting point:: 236-240 °C
Boiling point:: 424.5±45.0 °C(Predicted)
Density: 1.282±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: solid
pka: 9.86±0.20(Predicted)
color: White to Almost white
InChI: InChI=1S/C9H9NO2/c11-7-2-3-8-6(5-7)1-4-9(12)10-8/h2-3,5,11H,1,4H2,(H,10,12)
InChIKey: HOSGXJWQVBHGLT-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(O)C=C2)CCC1=O
CAS DataBase Reference: 54197-66-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933790002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2855
Product name: Cilostazol Related Compound A
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 100MG
Price: $499
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1134164
Product name: Cilostazol Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $1200
Updated: 2025/07/31

Sigma-Aldrich

Product number: 675350
Product name: 6-Hydroxy-3,4-dihydro-2(1H)-quinolinone
Purity: 97%
Packaging: 1g
Price: $27.1
Updated: 2023/06/20

TCI Chemical

Product number: D3448
Product name: 3,4-Dihydro-6-hydroxy-2(1H)-quinolinone
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: D3448
Product name: 3,4-Dihydro-6-hydroxy-2(1H)-quinolinone
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $160
Updated: 2025/07/31

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6-Hydroxy-2(1H)-3,4-dihydroquinolinone Chemical Properties,Usage,Production

Chemical Properties

6-Hydroxy-2(1H)-3,4-dihydroquinolinone Appearance is white to almost white powder to crystal, Melting point 238°C, Store at -20° C.

Uses

A metabolite of Cilostazole.

Synthesis

19313-87-2

54197-66-9

2) 98 g of 3-chloro-N-(4-methoxyphenyl)acrylamide obtained from step 1) was mixed with N-(4-methoxyphenyl)-3-chloroacrylamide, 500 mL of tetrahydrofuran and 98 g of palladium chloride. The reaction mixture was heated to 100 °C under 5 MPa pressure and maintained at that temperature. Upon completion of the reaction, it was cooled to room temperature and then maintained at 110°C for 3 hours. Subsequently, filtration was performed and the filtrate was rotary evaporated to dryness to obtain 6-hydroxy-3,4-dihydro-2(1H)-quinolone crude.3) The 6-hydroxy-3,4-dihydro-2(1H)-quinolone crude obtained in step 2) was dissolved in 50 mL of ethanol, recrystallized and decolorized using activated carbon. After filtration, 74 g of 6-hydroxy-3,4-dihydro-2(1H)-quinolinone was obtained as an off-white solid in 95% yield. The total yield was 85%.

References

[1] Patent: CN108383781, 2018, A. Location in patent: Paragraph 0033; 0034
[2] Patent: CN107325078, 2017, A. Location in patent: Paragraph 0039-0040; 0043-0044; 0046-0047; 0049-0050; 0052
[3] Journal of the Chinese Chemical Society, 2000, vol. 47, # 1, p. 155 - 162
[4] Heterocycles, 2009, vol. 78, # 1, p. 189 - 195
[5] Asian Journal of Chemistry, 2011, vol. 23, # 4, p. 1655 - 1660

6-Hydroxy-2(1H)-3,4-dihydroquinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

Disperse Yellow HG Nedocromil

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6-Hydroxy-2(1H)-3,4-dihydroquinolinone Suppliers

Americas 1 Canada 3 China 288 Europe 3 Germany 2 India 48 Japan 2 Slovakia 1 Switzerland 3 Ukraine 2 United Kingdom 12 United States 37 Global 402

Nanjing Xinsi Chemical Co., Ltd.

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Adamas Reagent, Ltd.

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View Lastest Price from 6-Hydroxy-2(1H)-3,4-dihydroquinolinone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 6-Hydroxy-3,4-dihydroquinolin-2(1H)-one 54197-66-9
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1000kg
Release date: 2025-06-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: 6-Hydroxy-2(1H)-3,4-dihydroquinolinone 54197-66-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2024-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Hydroxy-2(1H)-3,4-dihydroquinolinone 54197-66-9
Price: US $886.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 98%
Supply Ability: 1T
Release date: 2020-06-28

54197-66-9, 6-Hydroxy-2(1H)-3,4-dihydroquinolinoneRelated Search:

1,3-Dihydroxyacetone Triclosan Dihydromyrcenol 1-Hydroxyethylidene-1,1-diphosphonic acid Butylated Hydroxytoluene CHLOROPHOSPHONAZO III 2-Quinolinol 6-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE,6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE 6-Hydroxy-1-tetralone 5-AZIDO-VALERIANIC ACID 3-azidopropanoic acid Cilostazol 6-Methoxy-3,4-dihydro-1H-quinolin-2-one Cilostazol Related Compound C (50 mg) (1-(4-(5-Cyclohexyl-1H-tetrazol-1-yl)butyl)-6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one) Cilostazol Impurity GJXNGCFWGJQETE-UHFFFAOYSA-N 4-CIS-HYDROXY CILOSTAZOL 6-[3-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL) PROPOXY]-2(1H)-QUINOLINONE

6-HYDROXY-1,2,3,4-TETRAHYDRO-2-QUINOLINONE

6-HYDROXY-2(1H)-3,4-DIHYDROQUINOLINONE

6-HQ

6-HYDROXYL-3,4-DIHYDROCARBOSTYRIL

6-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE

TQ(3,4-Dihydro-6-Hydroxy-2(1H)CQuinolinone)

TQ(3,4-DIHYDRO-6-HYDROXY-2(1H)QUINOLINONE)

Hydroxyl-3,4-dihydrocarbostyril

6-Hydroxy-1,2,3,4-tetrahydro-2-quinolinone, 6-Hydroxy-3,4-dihydrocarbstyril

3,4-Dihydro-2,6-quinolinediol

3,4-Dihydro-6-hydroxyquinoline-2(1H)-one

6-Hydroxy-3,4-dihydroquinoline-2(1H)-one

AURORA KA-4814

2(1H)-Quinolinone, 3,4-dihydro-6-hydroxy-

6-Hydroxy-3,4-dihydro-2(1H)-quinolinone,6-Hydroxy-1,2,3,4-tetrahydro-2-quinolinone, 6-Hydroxy-3,4-dihydrocarbstyril

4-tetrahydroquinoline

6-Hydroxy-2-oxo-1

Cilostazol Related Compound A (50 mg) (6-hydroxy-3,4-dihydro-1H-quinolin-2-one)

6-Hydroxy-3,4-dihydro-2(1H)-quinolinone 6-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline

Cilostazol Related CoMpound A

6-hydroxy-3,4-dihydroquinazolone (Cilostazol)

6-Hydroxy-3,4-dihydro-2(1<i>H</i>)-quinolinone

6-Hydroxy-3,4-dihydro-2(1H)-quinolinone 97%

3,4-Dihydro-6-hydroxy-2(1<i>H</i>)-quinolinone

Cilostazol USP Related Compound A

Brexpiprazole Impurity 72

6-Hydroxy-3,4-Dihydroquinolinone(For Cilostazol)

3,4-Dihydro-6-hydroxyquinolin-2(1H)-one 98%

1,2,3,4-Tetrahydro-6-hydroxy-2-oxoquinoline

6-Hydroxy-2(1H)-3,4-dihydroquinolinone (Cilostazol)

3,4-DIHYDRO-6-HYDROXYQUINOLINONE

3,4-DIHYDRO-6-HYDROXY-2(1H)-QUINOLINONE

6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE (6-HQ)

6-Hydroxyl-3.4-dihydro-2-(1H)-quinolinone

Intermediate of Cilostazol

6-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE

6-HYDROXY-3,4-DIHYDRO-2-QUINOLINONE

6-HYDROXY-3,4-DIHYDROCARBOSTYRIL

6-HYDROXY-3,4-DIHYDROCARBSTYRIL

6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE

6-HYDROXY-3,4-DIHYDROQUINOLIN-2(1H)-ONE

6-HYDROXY-3,4-DIHYDROQUINOLONE

3,4-Dihydro-6-hydroxycarbostyril

3,4-Dihydro-6-hydroxy-carbostyril

6-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinolin

6-Hydroxy-3,4-dihydro-1H-quinoline-2-one

3,4-Dihydro-6-hydroxyquinolin-2(1H)-one

6-HYDROXY-2(1H)-3,4-DIHYDROQUINOLINONE CILOSTAZOL INTERMEDIATE

6-HIDROXY-2(1H)-3,4-DIHYDROQUINOLINONE

6-HYDRO-2(1H)-3,4-DIHYDROQUINOLINONE

6-Hydroxy-1,3,4-trihydroquinolin-2-one

The intermediate of Cilostazol

3,4-Dihydro-6-hydroxy-2-(IH)-quinolinone

6-Hydroxy-1,2,3,4-tetrahydro-2-oxoquinoline

Hydroxyl-3,4-Dihydrocarbostyril(ForCilostazol)

Q-2

3,4-Dihydro-6-hydroxycarbostyril-2(1H)quinolinone

6-Hydroxy-3,4-dihydro-1H-quinolin-2