Pyridine, 5-bromo-2-ethyl-
- Product Name
- Pyridine, 5-bromo-2-ethyl-
- CAS No.
- 38749-90-5
- Chemical Name
- Pyridine, 5-bromo-2-ethyl-
- Synonyms
- 5-BroMo-2-ethylpyridin;5-BroMo-2-ethylpyidine;5-Bromo-2-ethylpyridine;Pyridine, 5-bromo-2-ethyl-;Pyridine, 5-bromo-2-ethyl- (9CI);2-methylthiazole-37-carboxylic acid;Pyridine, 5-bromo-2-ethyl- ISO 9001：2015 REACH
- CBNumber
- CB91454946
- Molecular Formula
- C7H8BrN
- Formula Weight
- 186.05
- MOL File
- 38749-90-5.mol
Pyridine, 5-bromo-2-ethyl- Property
- Boiling point:
- 135-145 °C(Press: 150 Torr)
- Density
- 1.413±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.54±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B696128
- Product name
- 5-Bromo-2-ethylpyridine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B696128
- Product name
- 5-Bromo-2-ethylpyridine
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB144195
- Product name
- 5-Bromo-2-ethylpyridine
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- W5934
- Product name
- 5-Bromo-2-ethylpyridine
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 3H32-9-8N
- Product name
- 5-Bromo-2-ethylpyridine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
Pyridine, 5-bromo-2-ethyl- Chemical Properties,Usage,Production
Synthesis
624-28-2
557-20-0
38749-90-5
General procedure for the synthesis of 2-ethyl-5-bromopyridine from 2,5-dibromopyridine and diethylzinc: A suspension of 2,5-dibromopyridine (10 g, 42.21 mmol) and tetrakis(triphenylphosphine)palladium (Pd(PPh3)4, 2.43 g, 2.11 mmol) in tetrahydrofuran (THF, 100 mL) was slowly added to a suspension of 1 M diethyl Zinc (Et2Zn, 42.2 mL, 42.21 mmol). The reaction mixture was stirred at 0 °C for 30 min, then warmed up to room temperature and continued stirring for 1 h. The reaction was completed with saturated carbon dioxide. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution and extracted with ethyl acetate (EtOAc). The combined organic layers were washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with 4% ethyl acetate/petroleum ether as eluent to afford 5-bromo-2-ethylpyridine as a light yellow liquid (3 g, 38% yield). Thin layer chromatography (TLC) Rf value was 0.6 (10% ethyl acetate/petroleum ether).1H NMR (400MHz, CDCl3): δ 8.57 (d, J=2.4Hz, 1H), 7.72-7.69 (m, 1H), 7.06 (d, J=8.0Hz, 1H), 2.81-2.75 (m, 2H), 1.29 (t, J= 8.0 Hz, 3H).
References
[1] Patent: WO2015/36759, 2015, A1. Location in patent: Page/Page column 198
[2] Patent: US2014/275182, 2014, A1. Location in patent: Paragraph 0374; 0375
[3] Patent: US8912227, 2014, B1. Location in patent: Page/Page column 74
[4] Patent: WO2015/134038, 2015, A1. Location in patent: Page/Page column 90
Pyridine, 5-bromo-2-ethyl- Preparation Products And Raw materials
Raw materials
Preparation Products
Pyridine, 5-bromo-2-ethyl- Suppliers
- Tel
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- sales@carbosynth.com
- Country
- United Kingdom
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- 6005
- Advantage
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View Lastest Price from Pyridine, 5-bromo-2-ethyl- manufacturers
- Product
- Pyridine, 5-bromo-2-ethyl- 38749-90-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-11
- Product
- Pyridine, 5-bromo-2-ethyl- 38749-90-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-31