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(S)-(+)-1,2-Propanediol

Product Name
(S)-(+)-1,2-Propanediol
CAS No.
4254-15-3
Chemical Name
(S)-(+)-1,2-Propanediol
Synonyms
(S)-Propane-1,2-diol;(S)-1,2-PROPANEDIOL;(2S)-1,2-Propanediol;L-1,2-Propanediol;S-1,2-Propancdiol;(S)-(+)-PROPANEDIOL;(+)-1,2-Propanediol;(2S)-propane-1,2-diol;1,2-Propanediol, (S)-;PROPYELENE GLYCOL pure
CBNumber
CB9145670
Molecular Formula
C3H8O2
Formula Weight
76.09
MOL File
4254-15-3.mol
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(S)-(+)-1,2-Propanediol Property

Melting point:
-59 °C
Boiling point:
186-188 °C765 mm Hg(lit.)
alpha 
16 º (c=neat)
Density 
1.036 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.432(lit.)
Flash point:
225 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Miscible with acetone, chloroform, ethanol (95%), glycerin, and water; soluble at 1 in 6 parts of ether; not miscible with light mineral oil or fixed oils, but will dissolve some essential oils.
pka
14.49±0.20(Predicted)
form 
Liquid
color 
Clear colorless
Specific Gravity
1.04
optical activity
[α]20/D +16.5°, neat
explosive limit
2.6-12.6%(V)
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,7855
BRN 
1718871
Stability:
Volatile
CAS DataBase Reference
4254-15-3(CAS DataBase Reference)
NIST Chemistry Reference
(S)-(+)-1,2-Propanediol(4254-15-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
24/25-36/37/39-26
WGK Germany 
1
HS Code 
29053200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
540250
Product name
(S)-(+)-1,2-Propanediol
Purity
96%
Packaging
5g
Price
$34.98
Updated
2024/03/01
Sigma-Aldrich
Product number
540250
Product name
(S)-(+)-1,2-Propanediol
Purity
96%
Packaging
25g
Price
$150
Updated
2024/03/01
TCI Chemical
Product number
P1129
Product name
(S)-(+)-1,2-Propanediol
Purity
>98.0%(GC)
Packaging
5g
Price
$49
Updated
2024/03/01
TCI Chemical
Product number
P1129
Product name
(S)-(+)-1,2-Propanediol
Purity
>98.0%(GC)
Packaging
25g
Price
$242
Updated
2024/03/01
Alfa Aesar
Product number
B21773
Product name
(S)-(+)-1,2-Propanediol, 97%
Packaging
1g
Price
$57.65
Updated
2024/03/01
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(S)-(+)-1,2-Propanediol Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Chemical Properties

Propylene glycol is a clear, colorless, viscous, practically odorless liquid, with a sweet, slightly acrid taste resembling that of glycerin.

Uses

(S)-(+)-1,2-Propanediol acts as an organic solvent and diluent used in pharmaceutical preparations. It is also used as a chiral synthetic intermediate and substrate for enzyme studies.

Definition

ChEBI: (S)-propane-1,2-diol is a propane-1,2-diol. It has a role as a human metabolite and an Escherichia coli metabolite. It is an enantiomer of a (R)-propane-1,2-diol.

Production Methods

Propylene is converted to chlorohydrin by chlorine water and hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2- propylene oxide is converted to propylene glycol.

Pharmaceutical Applications

Propylene glycol has become widely used as a solvent, extractant, and preservative in a variety of parenteral and nonparenteral pharmaceutical formulations. It is a better general solvent than glycerin and dissolves a wide variety of materials, such as corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is similar to glycerin and only slightly less effective than ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film-coating formulations.
Propylene glycol is also used in cosmetics and in the food industry as a carrier for emulsifiers and as a vehicle for flavors in preference to ethanol, since its lack of volatility provides a more uniform flavor.

Safety

Propylene glycol is used in a wide variety of pharmaceutical formulations and is generally regarded as a relatively nontoxic material. It is also used extensively in foods and cosmetics. Probably as a consequence of its metabolism and excretion, propylene glycol is less toxic than other glycols. Propylene glycol is rapidly absorbed from the gastrointestinal tract; there is also evidence that it is absorbed topically when applied to damaged skin. It is extensively metabolized in the liver, mainly to lactic and pyruvic acids, and is also excreted unchanged in the urine.
In topical preparations, propylene glycol is regarded as minimally irritant,although it is more irritant than glycerin. There have been some reports of contact dermatitis associated with propylene glycol.Some local irritation is produced upon application to mucous membranes or when it is used under occlusive conditions.Parenteral administration may cause pain or irritation when propylene glycol is used in high concentration. Propylene glycol is estimated to be one-third as intoxicating as ethanol, with administration of large volumes being associated with adverse effects most commonly on the central nervous system, especially in neonates and children.Other adverse reactions reported, though generally isolated, include: ototoxicity;cardiovascular effects; seizures; and hyperosmolarity and lactic acidosis, both of which occur most frequently in patients with renal impairment. Adverse effects are more likely to occur following consumption of large quantities of propylene glycol or on adminstration to neonates, children under 4 years of age, pregnant women, and patients with hepatic or renal failure. Adverse events may also occur in patients treated with disulfiram or metronidazole.
On the basis of metabolic and toxicological data, the WHO has set an acceptable daily intake of propylene glycol at up to 25 mg/kg body-weight.Formulations containing 35% propylene glycol can cause hemolysis in humans.
In animal studies, there has been no evidence that propylene glycol is teratogenic or mutagenic. Rats can tolerate a repeated oral daily dose of up to 30 mL/kg body-weight in the diet over 6 months, while the dog is unaffected by a repeated oral daily dose of 2 g/kg in the diet for 2 years.
(mouse, IP): 9.72 g/kg
(mouse, IV): 6.63 g/kg
(mouse, oral): 22.0 g/kg
(mouse, SC): 17.34 g/kg
(rat, IM): 0.01 g/kg
(rat, IP): 6.66 g/kg
(rat, IV): 6.42 g/kg
(rat, oral): 0.02 g/kg
(rat, SC): 22.5 g/kg

storage

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed container, protected from light, in a cool, dry place.

Incompatibilities

Propylene glycol is incompatible with oxidizing reagents such as potassium permanganate.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; inhalations; ophthalmic, oral, otic, percutaneous, rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

(S)-(+)-1,2-Propanediol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-1,2-Propanediol Suppliers

Shanghai YouPeng Chemical Co. Ltd.
Tel
021-69005955 13701776567
Fax
021-69005775
Email
youpengchem@163.com
Country
China
ProdList
4304
Advantage
56
Weifang Huitao Chemical Co., Ltd
Tel
0536-7575896 15265815226
Email
3521744709@qq.com
Country
China
ProdList
43
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7508
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
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View Lastest Price from (S)-(+)-1,2-Propanediol manufacturers

Henan Fengda Chemical Co., Ltd
Product
(S)-(+)-1,2-Propanediol 4254-15-3
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-23
Hebei Guanlang Biotechnology Co., Ltd.
Product
(S)-(+)-1,2-Propanediol 4254-15-3
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-07-05
Career Henan Chemical Co
Product
(S)-(+)-1,2-Propanediol 4254-15-3
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-07-09

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