ChemicalBook > CAS DataBase List > (S)-(+)-1,2-Propanediol

(S)-(+)-1,2-Propanediol

Product Name
(S)-(+)-1,2-Propanediol
CAS No.
4254-15-3
Chemical Name
(S)-(+)-1,2-Propanediol
Synonyms
(S)-Propane-1,2-diol;(S)-1,2-PROPANEDIOL;(2S)-1,2-Propanediol;L-1,2-Propanediol;S-1,2-Propancdiol;(S)-(+)-PROPANEDIOL;(+)-1,2-Propanediol;(2S)-propane-1,2-diol;1,2-Propanediol, (S)-;PROPYELENE GLYCOL pure
CBNumber
CB9145670
Molecular Formula
C3H8O2
Formula Weight
76.09
MOL File
4254-15-3.mol
More
Less

(S)-(+)-1,2-Propanediol Property

Melting point:
-59 °C
Boiling point:
186-188 °C765 mm Hg(lit.)
alpha 
16 º (c=neat)
Density 
1.036 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.432(lit.)
Flash point:
225 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Miscible with acetone, chloroform, ethanol (95%), glycerin, and water; soluble at 1 in 6 parts of ether; not miscible with light mineral oil or fixed oils, but will dissolve some essential oils.
pka
14.49±0.20(Predicted)
form 
Liquid
color 
Clear colorless
Specific Gravity
1.04
optical activity
[α]20/D +16.5°, neat
explosive limit
2.6-12.6%(V)
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,7855
BRN 
1718871
Stability:
Volatile
CAS DataBase Reference
4254-15-3(CAS DataBase Reference)
NIST Chemistry Reference
(S)-(+)-1,2-Propanediol(4254-15-3)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
24/25-36/37/39-26
WGK Germany 
1
HS Code 
29053200
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
540250
Product name
(S)-(+)-1,2-Propanediol
Purity
96%
Packaging
5g
Price
$34.98
Updated
2024/03/01
Sigma-Aldrich
Product number
540250
Product name
(S)-(+)-1,2-Propanediol
Purity
96%
Packaging
25g
Price
$150
Updated
2024/03/01
TCI Chemical
Product number
P1129
Product name
(S)-(+)-1,2-Propanediol
Purity
>98.0%(GC)
Packaging
5g
Price
$49
Updated
2024/03/01
TCI Chemical
Product number
P1129
Product name
(S)-(+)-1,2-Propanediol
Purity
>98.0%(GC)
Packaging
25g
Price
$242
Updated
2024/03/01
Alfa Aesar
Product number
B21773
Product name
(S)-(+)-1,2-Propanediol, 97%
Packaging
1g
Price
$57.65
Updated
2024/03/01
More
Less

(S)-(+)-1,2-Propanediol Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Chemical Properties

Propylene glycol is a clear, colorless, viscous, practically odorless liquid, with a sweet, slightly acrid taste resembling that of glycerin.

Uses

(S)-(+)-1,2-Propanediol acts as an organic solvent and diluent used in pharmaceutical preparations. It is also used as a chiral synthetic intermediate and substrate for enzyme studies.

Definition

ChEBI: (S)-propane-1,2-diol is a propane-1,2-diol. It has a role as a human metabolite and an Escherichia coli metabolite. It is an enantiomer of a (R)-propane-1,2-diol.

Production Methods

Propylene is converted to chlorohydrin by chlorine water and hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2- propylene oxide is converted to propylene glycol.

Pharmaceutical Applications

Propylene glycol has become widely used as a solvent, extractant, and preservative in a variety of parenteral and nonparenteral pharmaceutical formulations. It is a better general solvent than glycerin and dissolves a wide variety of materials, such as corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is similar to glycerin and only slightly less effective than ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film-coating formulations.
Propylene glycol is also used in cosmetics and in the food industry as a carrier for emulsifiers and as a vehicle for flavors in preference to ethanol, since its lack of volatility provides a more uniform flavor.

Safety

Propylene glycol is used in a wide variety of pharmaceutical formulations and is generally regarded as a relatively nontoxic material. It is also used extensively in foods and cosmetics. Probably as a consequence of its metabolism and excretion, propylene glycol is less toxic than other glycols. Propylene glycol is rapidly absorbed from the gastrointestinal tract; there is also evidence that it is absorbed topically when applied to damaged skin. It is extensively metabolized in the liver, mainly to lactic and pyruvic acids, and is also excreted unchanged in the urine.
In topical preparations, propylene glycol is regarded as minimally irritant,although it is more irritant than glycerin. There have been some reports of contact dermatitis associated with propylene glycol.Some local irritation is produced upon application to mucous membranes or when it is used under occlusive conditions.Parenteral administration may cause pain or irritation when propylene glycol is used in high concentration. Propylene glycol is estimated to be one-third as intoxicating as ethanol, with administration of large volumes being associated with adverse effects most commonly on the central nervous system, especially in neonates and children.Other adverse reactions reported, though generally isolated, include: ototoxicity;cardiovascular effects; seizures; and hyperosmolarity and lactic acidosis, both of which occur most frequently in patients with renal impairment. Adverse effects are more likely to occur following consumption of large quantities of propylene glycol or on adminstration to neonates, children under 4 years of age, pregnant women, and patients with hepatic or renal failure. Adverse events may also occur in patients treated with disulfiram or metronidazole.
On the basis of metabolic and toxicological data, the WHO has set an acceptable daily intake of propylene glycol at up to 25 mg/kg body-weight.Formulations containing 35% propylene glycol can cause hemolysis in humans.
In animal studies, there has been no evidence that propylene glycol is teratogenic or mutagenic. Rats can tolerate a repeated oral daily dose of up to 30 mL/kg body-weight in the diet over 6 months, while the dog is unaffected by a repeated oral daily dose of 2 g/kg in the diet for 2 years.
(mouse, IP): 9.72 g/kg
(mouse, IV): 6.63 g/kg
(mouse, oral): 22.0 g/kg
(mouse, SC): 17.34 g/kg
(rat, IM): 0.01 g/kg
(rat, IP): 6.66 g/kg
(rat, IV): 6.42 g/kg
(rat, oral): 0.02 g/kg
(rat, SC): 22.5 g/kg

storage

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed container, protected from light, in a cool, dry place.

Incompatibilities

Propylene glycol is incompatible with oxidizing reagents such as potassium permanganate.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; inhalations; ophthalmic, oral, otic, percutaneous, rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

(S)-(+)-1,2-Propanediol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(S)-(+)-1,2-Propanediol Suppliers

Americas 1 Austria 1 Belgium 2 China 246 Europe 4 France 1 Germany 9 India 11 Japan 5 Slovakia 1 South Korea 2 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 18 United States 53 Global 357
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6024
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Combi-Blocks, Inc.
Tel
--
Fax
--
Email
les@combi-blocks.com
Country
United States
ProdList
2555
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
OX CHEM
Tel
--
Fax
--
Email
sales@ox-chem.com
Country
United States
ProdList
759
Advantage
50
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Accela ChemBio Inc.
Tel
--
Fax
--
Email
info@accelachem.com
Country
United States
ProdList
1054
Advantage
50
TCI America, Inc. (part of Tokyo Chemical Industry)
Tel
--
Fax
--
Email
Angelina.Crew@tcichemicals.com
Country
United States
ProdList
2053
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Strem Chemicals, Inc.
Tel
--
Fax
--
Email
info@strem.com
Country
United States
ProdList
4910
Advantage
86
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
CNH Technologies, Inc.
Tel
--
Fax
--
Email
info@cnhtechnologies.com
Country
United States
ProdList
353
Advantage
42
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
RnD SciChem, LLC
Tel
--
Fax
--
Email
rndscichem@gmail.com
Country
United States
ProdList
569
Advantage
0
Ring Specialty Chemicals Inc.
Tel
--
Fax
--
Email
info@ringchemicals.com
Country
United States
ProdList
888
Advantage
39
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
srlmarketing@dishnetdsl.net
Country
United States
ProdList
1905
Advantage
64
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Dow Chemical Company
Tel
--
Fax
--
Email
dowcig@dow.com
Country
United States
ProdList
770
Advantage
90
Lyondell Chemical Company
Tel
--
Fax
--
Country
United States
ProdList
79
Advantage
81
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Ennova MedChem Group Inc., formerly Arch Corporation
Tel
--
Fax
--
Email
sales@ennovamedchem.com
Country
United States
ProdList
1218
Advantage
42
Digital Specialty Chemicals, Inc.
Tel
--
Fax
--
Email
sales@digitalchem.com
Country
United States
ProdList
710
Advantage
85
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
BASF Corporation
Tel
--
Fax
--
Country
United States
ProdList
573
Advantage
86
More
Less

View Lastest Price from (S)-(+)-1,2-Propanediol manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
(S)-(+)-1,2-Propanediol 4254-15-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Hebei Chuanghai Biotechnology Co,.LTD
Product
(S)-(+)-1,2-Propanediol 4254-15-3
Price
US $19.00/KG
Min. Order
1KG
Purity
98.5%
Supply Ability
100tons
Release date
2024-08-23
Henan Fengda Chemical Co., Ltd
Product
(S)-(+)-1,2-Propanediol 4254-15-3
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-23

4254-15-3, (S)-(+)-1,2-PropanediolRelated Search:

1,3-Propanediol Propylene glycol 2-METHYL-1,3-PROPANEDIOL Propylene oxide Glycerol PROPYLENE 3-Amino-1,2-propanediol 1-Methoxy-2-propyl acetate (R)-(-)-1,2-Propanediol Poly(propylene glycol) PROPYLENE GLYCOL 1-Methoxy-2-propanol 2-ETHYL-2-(HYDROXYMETHYL)-1 3-PROPANEDIOL MONOOLEATE 2-HYDROXYMETHYL-2-METHYL-1,3-PROPANEDIOL 2-NITRO-2-PHENYL-1,3-PROPANEDIOL 3-ALLYLOXY-1,2-PROPANEDIOL isooctadecanoic acid, monoester with propane-1,2-diol Batyl alcohol

  • (S)-(+)-1,2-Dihydroxypropane (S)-(+)-Propylene Glycol
  • (S)-(+)-1,2-Propanediol,97%
  • (S)-(+)-1,2-Propanediol,99%
  • 1,2-Propanediol, (S)-
  • (2S)-propane-1,2-diol
  • S-1,2-Propancdiol
  • L-1,2-Propanediol
  • PROPYELENE GLYCOL pure
  • PROPYLENE GLYCOL extrapure AR
  • (2S)-1,2-Propanediol
  • (S)-(+)-1,2-Propanediol,96%
  • (S)-(+)-1,2-Propanediol, 96% 5GR
  • Синонимы: Монопропиленгликоль, 1,2-пропиленгликоль, 1,2-пропандиол, 1,2-диоксипропан метилгликоль, 1,2- дигидроксипропан, пропандиол-1,2, Propylene Glycol, Propane-1,2-diol, Monopropylene Glycol, MPG
  • (S)-(+)-1,2-Propanediol 96%
  • (S)-(+)-propylene glycero
  • (S)-(+)-1,2-PROPANEDIOL FOR SYNTHESIS
  • (S)-(+)-Propane-1,2-diol
  • (S)-Propane-1,2-diol
  • L-(+)-PROPYLENE GLYCOL
  • (S)-(+)-PROPANEDIOL
  • (S)-(+)-PROPYLENE GLYCEROL
  • (S)-(+)-PROPYLENE GLYCOL
  • (S)-(+)-1,2-DIHYDROXYPROPANE
  • (S)-(+)-1,2-PROPANEDIOL
  • (S)-1,2-PROPANEDIOL
  • 1,2-PROPANEDIOL, 1000MG, NEAT
  • ALUMINUM NITRATE NONAHYDRATE 98+% &
  • (S)-(+)-1,2-Propanediol&gt
  • 1,2-Propanediol, (2S)-
  • S-(+)-1.2-propylene glycol
  • 1,2-Propanediol, (S)-(9CI)
  • (+)-1,2-Propanediol
  • 4254-15-3
  • 4253-15-3
  • C3H8O2
  • Organic Building Blocks
  • Polyols
  • Simple Alcohols (Chiral)
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • organic alcohol
  • Chiral Building Blocks
  • Simple Alcohols (Chiral)
  • Synthetic Organic Chemistry
  • Chiral Compound
  • chiral
  • Chiral Compounds
  • Diols
  • bc0001
  • 4254-15-3