methyl 3-chlorosulfonylbenzoate
- Product Name
- methyl 3-chlorosulfonylbenzoate
- CAS No.
- 63555-50-0
- Chemical Name
- methyl 3-chlorosulfonylbenzoate
- Synonyms
- methyl 3-chlorosulfonylbenzoate;Methyl benzoate-3-sulfonyl chloride;3-(Methoxycarbonyl)benzenesulfonyl chloride;3-(Methoxycarbonyl)benzenesulphonyl chloride;Benzoic acid,3-(chlorosulfonyl)-, Methyl ester
- CBNumber
- CB91456894
- Molecular Formula
- C8H7ClO4S
- Formula Weight
- 234.66
- MOL File
- 63555-50-0.mol
methyl 3-chlorosulfonylbenzoate Property
- Boiling point:
- 345.6±25.0 °C(Predicted)
- Density
- 1.431
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- color
- light orange
- InChI
- InChI=1S/C8H7ClO4S/c1-13-8(10)6-3-2-4-7(5-6)14(9,11)12/h2-5H,1H3
- InChIKey
- SQIBNKUEUWGZBH-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC(S(Cl)(=O)=O)=C1
- EPA Substance Registry System
- Benzoic acid, 3-(chlorosulfonyl)-, methyl ester (63555-50-0)
Safety
- RIDADR
- 3261
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M295643
- Product name
- Methyl3-(chlorosulfonyl)benzoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M295643
- Product name
- Methyl3-(chlorosulfonyl)benzoate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- OR3564
- Product name
- Methyl3-(chlorosulphonyl)benzoate
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- W7545
- Product name
- Methyl3-(chlorosulfonyl)benzoate
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
- Product number
- 020428
- Product name
- 3-Chlorosulfonyl-benzoic acid methyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
methyl 3-chlorosulfonylbenzoate Chemical Properties,Usage,Production
Uses
Methyl 3-(chlorosulfonyl)benzoate
Synthesis
67-56-1
4052-92-0
63555-50-0
General procedure for the synthesis of methyl 3-(chlorosulfonyl)benzoate from methanol and 3-chlorosulfonylbenzoyl chloride: 3-(chlorosulfonyl)benzoic acid chloride (2.4 g) was dissolved in dichloromethane (20 mL) and cooled to 0 °C. Pyridine (791 mg) and methanol (320 mg) were added sequentially under stirring. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was filtered and washed with a solvent mixture of ethyl acetate and isopropyl ether. The filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography with hexane-ethyl acetate (9:1→4:1) as eluent to afford the target compound methyl 3-(chlorosulfonyl)benzoate (2.17 g, 92% yield) as colorless oil. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 3.99 (3H, s), 7.74 (1H, t, J=8.1 Hz), 8.21-8.24 (1H, m), 8.39-8.43 (1H, m), 8.69-8.70 (1H, m).
References
[1] Patent: EP1728793, 2006, A1. Location in patent: Page/Page column 127
[2] Patent: WO2006/36024, 2006, A1. Location in patent: Page/Page column 156
[3] Patent: EP2336107, 2015, B1. Location in patent: Paragraph 0296
[4] Recueil des Travaux Chimiques des Pays-Bas, 1921, vol. 40, p. 726
[5] Patent: WO2007/23186, 2007, A1. Location in patent: Page/Page column 49
methyl 3-chlorosulfonylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from methyl 3-chlorosulfonylbenzoate manufacturers
- Product
- methyl 3-chlorosulfonylbenzoate 63555-50-0
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g； 1kg; 25kg
- Release date
- 2020-01-10
- Product
- methyl 3-chlorosulfonylbenzoate 63555-50-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-20