ChemicalBook > CAS DataBase List > 4-ethoxy-1,1,1-trichloro-3-buten-2-one

4-ethoxy-1,1,1-trichloro-3-buten-2-one

Product Name
4-ethoxy-1,1,1-trichloro-3-buten-2-one
CAS No.
83124-74-7
Chemical Name
4-ethoxy-1,1,1-trichloro-3-buten-2-one
Synonyms
Regadenoson Impurity 14;1,1,1-Trichloro-4-ethoxy-...;4-ethoxy-1,1,1-trichloro-3-buten-2-one;1-Ethoxy-4,4,4-trichloro-3-oxo-1-butene;3-Buten-2-one, 1,1,1-trichloro-4-ethoxy-;(3E)-1,1,1-Trichloro-4-ethoxy-3-buten-2-one;4-ethoxy-1,1,1-trichloro-3-buten-2-one ISO 9001：2015 REACH
CBNumber
CB91457154
Molecular Formula
C6H7Cl3O2
Formula Weight
217.48
MOL File
83124-74-7.mol
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4-ethoxy-1,1,1-trichloro-3-buten-2-one Property

Boiling point:
200℃
Density 
1.368
Flash point:
72℃
InChI
InChI=1S/C6H7Cl3O2/c1-2-11-4-3-5(10)6(7,8)9/h3-4H,2H2,1H3
InChIKey
VKNLVLNOHCTKII-UHFFFAOYSA-N
SMILES
C(Cl)(Cl)(Cl)C(=O)C=COCC
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
4999AJ
Product name
1,1,1-Trichloro-4-ethoxy-but-3-en-2-one
Packaging
1g
Price
$126
Updated
2021/12/16
AK Scientific
Product number
4999AJ
Product name
1,1,1-Trichloro-4-ethoxy-but-3-en-2-one
Packaging
5g
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050138
Product name
1,1,1-TRICHLORO-4-ETHOXYBUT-3-EN-2-ONE
Purity
95.00%
Packaging
5MG
Price
$499.57
Updated
2021/12/16
Crysdot
Product number
CD13009704U
Product name
4-Ethoxy-1,1,1-trichloro-3-buten-2-one
Purity
97%
Packaging
10g
Price
$108
Updated
2021/12/16
Crysdot
Product number
CD13009704U
Product name
4-Ethoxy-1,1,1-trichloro-3-buten-2-one
Purity
97%
Packaging
25g
Price
$216
Updated
2021/12/16
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4-ethoxy-1,1,1-trichloro-3-buten-2-one Chemical Properties,Usage,Production

Synthesis

109-92-2

76-02-8

83124-74-7

Under nitrogen protection, 218.4 g (1.2 mol) of trichloroacetyl chloride was added to a dry round-bottomed flask and the flask was cooled to 0 °C in an ice bath. Subsequently, 172.8 g (2.4 mol) of ethyl vinyl ether was slowly added dropwise to the flask and the reaction temperature was maintained at 0 °C. The reaction mixture was stirred thoroughly under nitrogen atmosphere. After that, the reaction system was slowly warmed to 30 °C and stirring was continued at this temperature for 10 hours to ensure complete reaction. After completion of the reaction, the reaction mixture was refluxed for 3 hours. Finally, the product was purified by distillation under reduced pressure to afford 247.2 g of 1,1,1-trichloro-4-ethoxy-3-buten-2-one as a pale yellow oil (boiling point 117-119 °C, pressure 13 mmHg) in 96.5% yield.

References

[1] Patent: CN107056608, 2017, A. Location in patent: Paragraph 0023; 0024
[2] Chemische Berichte, 1982, vol. 115, p. 2766 - 2782
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 1, p. 254 - 257
[4] Patent: CN105503878, 2016, A. Location in patent: Paragraph 0010
[5] Synlett, 2008, # 11, p. 1684 - 1686

4-ethoxy-1,1,1-trichloro-3-buten-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-ethoxy-1,1,1-trichloro-3-buten-2-one manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-ethoxy-1,1,1-trichloro-3-buten-2-one 83124-74-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-09
Career Henan Chemical Co
Product
4-ethoxy-1,1,1-trichloro-3-buten-2-one 83124-74-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2018-08-06

83124-74-7, 4-ethoxy-1,1,1-trichloro-3-buten-2-oneRelated Search:

Ethyl 3,3-Diethoxypropionate 2-HYDROXYADENOSINE 2-Hydrazinoadenosine 2-Chloroadenosine REGADENOSON 2-CHLORO-6-AMINO-9-(2',3',5'-TRI-O-ACETYL-?-D-RIBOFURANOSYL)PURINE Propanoicacid,2-formyl-3-oxo-,ethylester Ethyl pyrazole-4-carboxylate

  • 4-ethoxy-1,1,1-trichloro-3-buten-2-one
  • 1-Ethoxy-4,4,4-trichloro-3-oxo-1-butene
  • 1,1,1-Trichloro-4-ethoxy-...
  • Regadenoson Impurity 14
  • (3E)-1,1,1-Trichloro-4-ethoxy-3-buten-2-one
  • 3-Buten-2-one, 1,1,1-trichloro-4-ethoxy-
  • 4-ethoxy-1,1,1-trichloro-3-buten-2-one ISO 9001：2015 REACH
  • 83124-74-7