ChemicalBook > CAS DataBase List > 6-Chloro-3-formyl-2-picoline

6-Chloro-3-formyl-2-picoline

Product Name: 6-Chloro-3-formyl-2-picoline
CAS No.: 884495-36-7
Chemical Name: 6-Chloro-3-formyl-2-picoline
Synonyms: 6-Chloro-2-methylnicotinaldehyde;6-Chloro-2-Methyl-pyridine-3-carbaldehyde;6-Chloro-3-formyl-2-picoline;6-Chloro-2-methyl-3-pyridinecarbaldehyde;2-Methyl-6-chloropyridine-3-carboxaldehyde;6-Chloro-2-methyl-3-pyridinecarboxaldehyde;6-Chloro-2-methyl-pyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde, 6-chloro-2-Methyl-;6-Chloro-3-formyl-2-picoline ISO 9001：2015 REACH
CBNumber: CB91458252
Molecular Formula: C7H6ClNO
Formula Weight: 155.58
MOL File: 884495-36-7.mol

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6-Chloro-3-formyl-2-picoline Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid
InChI: InChI=1S/C7H6ClNO/c1-5-6(4-10)2-3-7(8)9-5/h2-4H,1H3
InChIKey: BLLSRSWUYXEXNF-UHFFFAOYSA-N
SMILES: C1(C)=NC(Cl)=CC=C1C=O

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C381198
Product name: 6-Chloro-3-formyl-2-picoline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C381198
Product name: 6-Chloro-3-formyl-2-picoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR959420
Product name: 6-Chloro-2-methylpyridine-3-carbaldehyde
Purity: 98%
Packaging: 1g
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: Z0990
Product name: 6-Chloro-3-formyl-2-methylpyridine
Packaging: 1g
Price: $201
Updated: 2021/12/16

Apolloscientific

Product number: OR959420
Product name: 6-Chloro-2-methylpyridine-3-carbaldehyde
Purity: 98%
Packaging: 5g
Price: $415
Updated: 2021/12/16

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6-Chloro-3-formyl-2-picoline Chemical Properties,Usage,Production

Uses

6-Chloro-3-formyl-2-picoline can be used as plasma kallikrein inhibitors.

Synthesis

132606-40-7

68-12-2

884495-36-7

Ether (Et2O) was added to a 3L three-neck flask followed by 5-bromo-2-chloro-6-methylpyridine (56.97 g, 0.28 mol). The reaction mixture was cooled to -78 °C and n-butyllithium (n-BuLi, 132 mL, 0.33 mol) was slowly added dropwise through the addition funnel while ensuring that the reaction temperature was maintained below -70 °C. After the dropwise addition was completed, the mixture was continued to be stirred at -78 °C for 30 min. Subsequently, N,N-dimethylformamide (DMF, 43 mL, 0.56 mol) was added dropwise at the same temperature. After completion of the dropwise addition, the cooling bath was removed and the reaction mixture was allowed to gradually warm up to room temperature and stirred for 1.5 hours. Upon completion of the reaction, the reaction was quenched with brine (300 mL). The organic and aqueous layers were separated and the aqueous layer was extracted with ether (150 mL). The organic layers were combined and adjusted to pH 3-4 with dilute hydrochloric acid (HCl) in a conical flask, then washed with saturated aqueous sodium bicarbonate (NaHCO3) (300 mL). The organic layer was separated and concentrated to dryness. The crude product was recrystallized from a solvent mixture of ether/hexane (200 mL, 1:1) to give a light yellow crystalline solid (19 g). The filtrate was concentrated and further purified by column chromatography (eluent: ethyl acetate/hexane, 1:9) to give another batch of product (13 g). Combining the two batches of products, the total yield was 71%. The structure of the product was confirmed by 1H NMR (CDCl3): δ 2.87 (s, 3H), 7.35 (d, 1H, J=9.0 Hz), 8.07 (d, 1H, J=9.0 Hz), 10.31 (s, 1H).

References

[1] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 50
[2] Patent: WO2014/28669, 2014, A1. Location in patent: Paragraph 00328

6-Chloro-3-formyl-2-picoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Chloro-3-formyl-2-picoline manufacturers

Dideu Industries Group Limited

Product: 6-Chloro-3-formyl-2-picoline 884495-36-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-30

Career Henan Chemical Co

Product: 6-Chloro-3-formyl-2-picoline 884495-36-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 2kg；10kg; 100kg
Release date: 2019-08-30

884495-36-7, 6-Chloro-3-formyl-2-picolineRelated Search:

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6-Chloro-3-formyl-2-picoline

6-Chloro-2-methyl-3-pyridinecarboxaldehyde

6-Chloro-2-methylnicotinaldehyde

6-Chloro-2-methyl-pyridine-3-carboxaldehyde

6-Chloro-2-Methyl-pyridine-3-carbaldehyde

3-Pyridinecarboxaldehyde, 6-chloro-2-Methyl-

2-Methyl-6-chloropyridine-3-carboxaldehyde

6-Chloro-3-formyl-2-picoline ISO 9001：2015 REACH

6-Chloro-2-methyl-3-pyridinecarbaldehyde

884495-36-7

Pyridine