2-bromo-3-methyl-phenol
- Product Name
- 2-bromo-3-methyl-phenol
- CAS No.
- 22061-78-5
- Chemical Name
- 2-bromo-3-methyl-phenol
- Synonyms
- 2-bromo-3-methyl-phenol;2-Bromo-3-hydroxytoluene;Phenol, 2-broMo-3-Methyl-;2-Bromo-3-methylphenol 98%;2-bromo-3-methyl-phenol USP/EP/BP
- CBNumber
- CB91458803
- Molecular Formula
- C7H7BrO
- Formula Weight
- 187.03
- MOL File
- 22061-78-5.mol
2-bromo-3-methyl-phenol Property
- Melting point:
- 58.5-59 °C
- Boiling point:
- 83-84 °C(Press: 4 Torr)
- Density
- 1.554±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 8.54±0.10(Predicted)
- color
- Light Brown
Safety
- HS Code
- 2907199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B697415
- Product name
- 2-Bromo-3-methylphenol
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 415786
- Product name
- 2-Bromo-3-methylphenol
- Packaging
- 250mg
- Price
- $319
- Updated
- 2021/12/16
- Product number
- 083795
- Product name
- 2-Bromo-3-methylphenol
- Purity
- 97%
- Packaging
- 500g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- 083795
- Product name
- 2-Bromo-3-methylphenol
- Purity
- 97%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 2701-9-10
- Product name
- 2-Bromo-3-methylphenol
- Purity
- 98%
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
2-bromo-3-methyl-phenol Chemical Properties,Usage,Production
Uses
2-Bromo-3-methylphenol is a reagent used in chemoselective and regioselective oxybromination of phenols with dioxygen
Synthesis
2835-97-4
22061-78-5
Step 1: 2-Amino-3-methylphenol (8a, 5.7 g, 46.3 mmol) was dissolved in a solvent mixture of water (30 mL) and 1,4-dioxane (15 mL). The reaction mixture was heated to reflux followed by slow dropwise addition of hydrobromic acid (48%, 17 mL, 0.31 mol) over 20 min. After the dropwise addition was completed, the reaction was continued at reflux for 15 min. The reaction solution was cooled to 0 °C and an aqueous solution of sodium nitrite (20 mL) was added over 30 min. Stirring was continued at 0 °C for 15 min, after which the reaction mixture was poured at once into a mixture of water (20 mL) and hydrobromic acid (48%, 17 mL, 0.31 mol) of cuprous bromide (I) (7.64 g, 53.2 mmol) that had been pre-cooled to 0 °C and treated to avoid light. After stirring at 0 °C for 15 min, the reaction solution was slowly warmed to 60 °C and stirring was continued for 15 min. It was then cooled to room temperature and stirred overnight. Upon completion of the reaction, the mixture was transferred to a partition funnel and extracted with ethyl acetate (3×). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give the crude product. Purification by CombiFlash fast chromatography system (eluent: 20% ethyl acetate/hexane) gave the target product 2-bromo-3-methylphenol (8b, 1.46 g, 17% yield) as a reddish brown oil.
References
[1] Patent: WO2009/62285, 2009, A1. Location in patent: Page/Page column 60-61
[2] Patent: WO2009/62308, 2009, A1. Location in patent: Page/Page column 70
[3] Patent: WO2009/62288, 2009, A1. Location in patent: Page/Page column 67
[4] Patent: WO2009/62289, 2009, A1. Location in patent: Page/Page column 74
[5] Journal of the Chemical Society, 1925, vol. 127, p. 498
2-bromo-3-methyl-phenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-bromo-3-methyl-phenol manufacturers
- Product
- 2-bromo-3-methyl-phenol 22061-78-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-18
- Product
- 2-bromo-3-methyl-phenol 22061-78-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2019-12-25