2-Chloro-3-methylpyridine-4-carboxaldehyde

Product Name: 2-Chloro-3-methylpyridine-4-carboxaldehyde
CAS No.: 790696-96-7
Chemical Name: 2-Chloro-3-methylpyridine-4-carboxaldehyde
Synonyms: 2-chloro-3-Methylisonicotinaldehyde;2-chloro-3-methylpyridine-4-carbaldehyde;2-Chloro-3-methylpyridine-4-carboxaldehyde;4-Pyridinecarboxaldehyde, 2-chloro-3-methyl-
CBNumber: CB91471118
Molecular Formula: C7H6ClNO
Formula Weight: 155.58
MOL File: 790696-96-7.mol

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2-Chloro-3-methylpyridine-4-carboxaldehyde Property

Boiling point:: 265.0±35.0 °C(Predicted)
Density: 1.269±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.62±0.10(Predicted)
form: solid
color: White

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: OR954175
Product name: 2-Chloro-3-methylisonicotinaldehyde
Purity: 97%
Packaging: 250mg
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0357714
Product name: 2-CHLORO-3-METHYLPYRIDINE-4-CARBOXALDEHYDE
Purity: 95.00%
Packaging: 5MG
Price: $505.44
Updated: 2021/12/16

AK Scientific

Product number: 2370AC
Product name: 2-chloro-3-methylisonicotinaldehyde
Packaging: 1g
Price: $1083
Updated: 2021/12/16

Apolloscientific

Product number: OR954175
Product name: 2-Chloro-3-methylisonicotinaldehyde
Purity: 97%
Packaging: 100mg
Price: $132
Updated: 2021/12/16

Ambeed

Product number: A149065
Product name: 2-chloro-3-methylisonicotinaldehyde
Purity: 97%
Packaging: 100mg
Price: $166
Updated: 2021/12/16

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2-Chloro-3-methylpyridine-4-carboxaldehyde Chemical Properties,Usage,Production

Synthesis

133928-64-0

790696-96-7

General procedure for the synthesis of 2-chloro-3-methylpyridine-4-carboxaldehyde from 2-chloro-N,3-dimethyl-N-phenyl-isonicotinamide: 2-chloro-N,3-dimethyl-N-phenyl-isonicotinamide (124.9 g, 479 mmol) was dissolved in CH2Cl2 (1300 mL) at -78 °C, and the slow dropwise addition of DIBAL (1 M THF solution. 719 mL, 719 mmol) over 1 hour. The reaction mixture continued to be stirred at this temperature for 2 hours. Subsequently, DIBAL (1M THF solution, 281 mL, 281 mmol) was added again and the reaction mixture was warmed to -60°C and stirred for 30 minutes. Slow addition of saturated aqueous sodium potassium tartrate (500 mL) was accomplished over 30 min, the cooling bath was removed, and the mixture was stirred at room temperature overnight. The reaction was quenched by the addition of water (100 mL) and the organic phase was separated. The aqueous phase was extracted with CH2Cl2 (2 x 100 mL) and the organic phases were combined. The organic phase was dried with MgSO4, filtered and concentrated under reduced pressure. The target product 2-chloro-3-methylpyridine-4-carboxaldehyde (58.35 g, 78% yield) was obtained by purification as light yellow crystals.

References

[1] Patent: WO2006/21402, 2006, A1. Location in patent: Page/Page column 44-45
[2] Patent: WO2006/21403, 2006, A1. Location in patent: Page/Page column 20-21
[3] Patent: WO2005/40120, 2005, A1. Location in patent: Page/Page column 24
[4] Patent: WO2005/40165, 2005, A1. Location in patent: Page/Page column 23
[5] Patent: WO2005/40173, 2005, A1. Location in patent: Page/Page column 34

2-Chloro-3-methylpyridine-4-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-3-methylpyridine-4-carboxaldehyde Suppliers

China 40 Germany 1 India 1 United States 4 Global 46

Hebei Summedchem Co.,Ltd

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790696-96-7, 2-Chloro-3-methylpyridine-4-carboxaldehydeRelated Search:

2-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID ETHYL 2-CHLORO-3-CYANO-6-METHYLISONICOTINATE 4-Chloro-2-(3-fluoroBenzyl)-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione ETHYL 6-(TERT-BUTYL)-2-CHLORO-3-CYANOISONICOTINATE 4-chloro-2-(2-chloro-6-fluoroBenzyl)-6-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione 2-CHLORO-3-METHYLPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER 4-Chloro-6-methyl-2-(4-methylbenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione 4-CHLORO-6-METHYL-2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE-1,3-DIONE 4-Chloro-6-methyl-2-[3-(trifluoromethyl)Benzyl]-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione ETHYL 2-CHLORO-3-CYANO-6-METHYL-5-NITROPYRIDINE-4-CARBOXYLATE 2-benzyl-4-chloro-6-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione 2-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-3,4-DICARBOXYLIC ACID RARECHEM AL BW 1166 4-chloro-6-methyl-2-(methylthio)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione 4-chloro-2-(2,4-dichlorobenzyl)-6-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione SPECS AO-801/41077570 6-(TERT-BUTYL)-4-CHLORO-2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE-1,3-DIONE RARECHEM AL BW 0413

2-Chloro-3-methylpyridine-4-carboxaldehyde

2-chloro-3-methylpyridine-4-carbaldehyde

2-chloro-3-Methylisonicotinaldehyde

4-Pyridinecarboxaldehyde, 2-chloro-3-methyl-

790696-96-7

pharmacetical