PHENYLGLYCINE-01

Product Name: PHENYLGLYCINE-01
CAS No.: 853138-65-5
Chemical Name: PHENYLGLYCINE-01
Synonyms: PG 01;PG-01,PG01;PHENYLGLYCINE-01;PG-01 >=98% (HPLC);PG01, 10 mM in DMSO;N-Methyl-N-[2-[[4-(1-Methylethyl)phenyl]amino]-2-1H-indole-3-acetamide;2-[(2-1H-indol-3-yl-acetyl)-methylamino]-N-(4-isopropylphenyl)-2-phenylacetamide;N-Methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-1H-indole-3-acetamide;1H-Indole-3-acetamide, N-methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-
CBNumber: CB91474942
Molecular Formula: C28H29N3O2
Formula Weight: 439.55
MOL File: 853138-65-5.mol

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PHENYLGLYCINE-01 Property

Boiling point:: 704.6±60.0 °C(Predicted)
Density: 1.217±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥10mg/mL
form: powder
pka: 13.31±0.70(Predicted)
color: white to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0027764
Product name: PG01
Purity: >98.0%
Packaging: 1mg
Price: $155
Updated: 2021/12/16

ApexBio Technology

Product number: B7545
Product name: PG01
Packaging: 10mg
Price: $282
Updated: 2021/12/16

ChemScene

Product number: CS-0027764
Product name: PG01
Purity: >98.0%
Packaging: 5mg
Price: $460
Updated: 2021/12/16

ChemScene

Product number: CS-0027764
Product name: PG01
Purity: >98.0%
Packaging: 10mg
Price: $780
Updated: 2021/12/16

ApexBio Technology

Product number: B7545
Product name: PG01
Packaging: 50mg
Price: $1190
Updated: 2021/12/16

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PHENYLGLYCINE-01 Chemical Properties,Usage,Production

Uses

PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (Ka of 0.3 μM). PG01 increases ΔF508-CFTR Cl- current after adding Forskolin[1][2].

in vivo

Pharmacokinetic analysis of PG01 in rats is done by serial measurements of plasma concentrations after single bolus infusions (5 mg/kg). PG01 pharmacokinetics fitted a two-compartment model with half-times of ＜5 min and 130 min with volume of distribution 4 L. Microsome metabolism studies and rat pharmacokinetic analysis suggests significantly more rapid metabolism of PG01 than SF-03^[1].

References

[1] Pedemonte N, et al. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol. 2005 May;67(5):1797-807. DOI:10.1124/mol.105.010959
[2] Caputo A, et al. Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators. J Pharmacol Exp Ther. 2009 Sep;330(3):783-91. DOI:10.1124/jpet.109.154146

PHENYLGLYCINE-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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PHENYLGLYCINE-01 Suppliers

China 30 United Kingdom 1 United States 7 Global 38

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853138-65-5, PHENYLGLYCINE-01Related Search:

PHENYLGLYCINE-01

N-Methyl-N-[2-[[4-(1-Methylethyl)phenyl]amino]-2-1H-indole-3-acetamide

PG 01

2-[(2-1H-indol-3-yl-acetyl)-methylamino]-N-(4-isopropylphenyl)-2-phenylacetamide

N-Methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-1H-indole-3-acetamide

1H-Indole-3-acetamide, N-methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-

PG-01 >=98% (HPLC)

PG-01,PG01

PG01, 10 mM in DMSO

853138-65-5

C28H29N3O2