6-BROMO-[1,8]NAPHTHYRIDIN-2-OL

Product Name: 6-BROMO-[1,8]NAPHTHYRIDIN-2-OL
CAS No.: 72754-05-3
Chemical Name: 6-BROMO-[1,8]NAPHTHYRIDIN-2-OL
Synonyms: 6-BroMo-[1,8]Naphthyridin-2-One;6-BroMo-1H-[1,8]naphthyridin-2-one;6-BroMo-2-hydroxy-1,8-naphthyridine;6-BROMO-[1,8]NAPHTHYRIDIN-2(1H)-ONE;1,8-Naphthyridin-2(1H)-one, 6-bromo-
CBNumber: CB91478667
Molecular Formula: C8H5BrN2O
Formula Weight: 225.04
MOL File: 72754-05-3.mol

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6-BROMO-[1,8]NAPHTHYRIDIN-2-OL Property

Melting point:: >300℃
Boiling point:: 415.9±45.0 °C(Predicted)
Density: 1.711
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 9.93±0.20(Predicted)
Appearance: Light yellow to light brown Solid
Water Solubility: Insoluble in water.

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38-22-41-37/38
Safety Statements: 22-26-36/37/39-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000844
Product name: 6-Bromo-1,8-naphthyridin-2-ol
Purity: Aldrich
Packaging: 1g
Price: $817
Updated: 2025/07/31

Oakwood

Product number: 211223
Product name: 6-Bromo-1,8-naphthyridin-2-ol
Packaging: 250mg
Price: $42
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144388
Product name: 6-Bromo-1,8-naphthyridin-2-ol
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Matrix Scientific

Product number: 048320
Product name: 6-Bromo-[1,8]naphthyridin-2(1H)-one
Purity: 95%
Packaging: 250mg
Price: $89
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144388
Product name: 6-Bromo-1,8-naphthyridin-2-ol
Packaging: 500mg
Price: $125
Updated: 2021/12/16

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6-BROMO-[1,8]NAPHTHYRIDIN-2-OL Chemical Properties,Usage,Production

Uses

6-Bromo-1,8-naphthyridin-2(1H)-one is used as an organic chemical synthesis intermediate.

Synthesis

894853-42-0

72754-05-3

Tert-butyl 3-(2-amino-5-bromopyridin-3-yl)acrylate (2.5 g, 8.35 mmol) was dissolved in anhydrous methanol (50 mL) and sodium methanolate (8.5 mL, 4.9 M solution, 41.75 mmol) was added. The reaction mixture was heated to reflux for 2 hours and subsequently cooled to room temperature. The mixture was cooled in an ice water bath and water (100 mL) was added with vigorous stirring to precipitate. The solid was collected by filtration and washed with water (20 mL). The filtrate was neutralized with 1 M aqueous hydrochloric acid, precipitated again, filtered and washed with water (20 mL). The solids obtained twice were combined and dried under reduced pressure to give the off-white target product 6-bromo-1,8-naphthyridin-2(1H)-one (1.75 g, 93% yield). The product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 8.43 (d, 1H, J=2.5Hz), 8.06 (d, 1H, J=2.5Hz), 7.60 (d, 1H, J=9.1Hz), 6.44 (d, 1H, J=9.1Hz); ESIMS m/z 225 (100%), 227 (100%) ) [C8H5N2OBr + H]+.

References

[1] Patent: WO2007/53131, 2007, A2. Location in patent: Page/Page column 203
[2] Patent: WO2015/186137, 2015, A1. Location in patent: Page/Page column 16

6-BROMO-[1,8]NAPHTHYRIDIN-2-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-[1,8]NAPHTHYRIDIN-2-OL Suppliers

China 64 Germany 1 India 2 United Kingdom 2 United States 9 Global 78

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View Lastest Price from 6-BROMO-[1,8]NAPHTHYRIDIN-2-OL manufacturers

Career Henan Chemical Co

Product: 6-BROMO-[1,8]NAPHTHYRIDIN-2-OL 72754-05-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2020-03-05

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72754-05-3