6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID

6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID Property

Melting point:

207 °C (decomp)

Boiling point:

437.4±25.0 °C(Predicted)

Density 

1.609±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Solid

pka

4.37±0.30(Predicted)

color 

Light brown to brown

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

DAO-IN-1 is a potent inhibitor of D-amino acid oxidase (DAO) with an IC50 value of 269 nM. DAO is an enzyme responsible for D-serine metabolism, D-serine is a co-agonist of NMDA receptors[1].

References

[1] Sparey T, et al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3386-91. DOI:10.1016/j.bmcl.2008.04.020