ChemicalBook > CAS DataBase List > (S)-1-Cbz-pyrrolidine-3-carboxylic acid
(S)-1-Cbz-pyrrolidine-3-carboxylic acid
- Product Name
- (S)-1-Cbz-pyrrolidine-3-carboxylic acid
- CAS No.
- 192214-00-9
- Chemical Name
- (S)-1-Cbz-pyrrolidine-3-carboxylic acid
- Synonyms
- N-Cbz-S-3-Pyrrolidinecarboxylic acid;(S)-1-Cbz-3-pyrrolidinecarboxylic acid;(S)-1-Cbz-pyrrolidine-3-carboxylic acid;(S)-1-N-Cbz-Pyrrolidine-3-carboxylic acid;(S)-1-Cbz-pyrrolidine-3-carboxylic acid - [P12341];(3S)-1-benzyloxycarbonylpyrrolidine-3-carboxylic acid;1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (3S)-
- CBNumber
- CB91500982
- Molecular Formula
- C13H15NO4
- Formula Weight
- 249.26
- MOL File
- 192214-00-9.mol
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(S)-1-Cbz-pyrrolidine-3-carboxylic acid Property
- Melting point:
- 96-98 °C
- Boiling point:
- 432.3±45.0 °C(Predicted)
- Density
- 1.309±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.46±0.20(Predicted)
- Appearance
- White to off-white Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C227645
- Product name
- (S)-1-Cbz-pyrrolidine-3-carboxylicacid
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC150808
- Product name
- (S)-1-Cbz-pyrrolidine-3-carboxylicacid
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
Activate Scientific
- Product number
- AS38518
- Product name
- (S)-1-cbz-Pyrrolidine-3-carboxylic acid
- Purity
- 97% ee
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC150808
- Product name
- (S)-1-Cbz-pyrrolidine-3-carboxylicacid
- Packaging
- 1g
- Price
- $410
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-W008576
- Product name
- (S)-1-Cbz-pyrrolidine-3-carboxylicacid
- Purity
- 99.01%
- Packaging
- 10g
- Price
- $444
- Updated
- 2021/12/16
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(S)-1-Cbz-pyrrolidine-3-carboxylic acid Chemical Properties,Usage,Production
Synthesis
501-53-1
193693-69-5
192214-00-9
Step 1: To a 100 mL round bottom flask was added (S)-1-Cbz-3-pyrrolidinecarbonitrile (2 g, 8.7 mmol) and concentrated hydrochloric acid (20 mL). The mixture was refluxed for 4.5 h before the solvent was removed by vacuum distillation and dried overnight using an oil pump. The crude product was dissolved in a solvent mixture of acetone (20 mL) and deionized water (20 mL). After cooling to 0 °C, sodium carbonate (2.8 g, 26 mmol) was added, followed by slow dropwise addition of benzyl chloroformate (5.5 mL, 9.6 mmol). The reaction mixture was allowed to warm up gradually to room temperature. After 7 hours of reaction, the solvent was removed by vacuum distillation. Deionized water (8 mL) was added and extracted twice with a solvent mixture of hexane:EtOAc = 1:1. The aqueous layer was acidified to pH 2 by the addition of concentrated hydrochloric acid and 0.5 M potassium bisulfate.Subsequently, the aqueous layer was extracted with ethyl acetate (four times), and the organic phase was dried over sodium sulfate and concentrated by vacuum to afford (S)-1-CBZ-3-carboxypyrrolidine (1.46 g, 67% yield), which was used directly in the next step.1H NMR (CDCl3, 400 MHz): δ 7.38-7.29 (m, 5H), 5.14 (d, J = 2.8 Hz, 2H), 3.72-3.43 (m, 4H), 3.17-3.09 (m, 1H), 2.21-2.14 (m, 2H).
References
[1] Patent: WO2011/160020, 2011, A2. Location in patent: Page/Page column 62
(S)-1-Cbz-pyrrolidine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-1-Cbz-pyrrolidine-3-carboxylic acid manufacturers
Career Henan Chemical Co
- Product
- (S)-1-Cbz-pyrrolidine-3-carboxylic acid 192214-00-9
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10
192214-00-9, (S)-1-Cbz-pyrrolidine-3-carboxylic acidRelated Search:
1,2,4-pyrrolidinetricarboxylic acid, 5-(5-oxazolyl)-2-(1H-pyrazol-1-ylmethyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)-
1,2,4-pyrrolidinetricarboxylic acid, 2-(2-methylpropyl)-5-(5-oxazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S,4S,5R)-
1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-pyrazol-1-ylmethyl)-5-(2-thienyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)-
(S)-1-Cbz-pyrrolidine-3-carboxylic acid
1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-imidazol-1-ylmethyl)-5-(5-oxazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)-
1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-imidazol-1-ylmethyl)-5-(2-thienyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)-
1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-pyrazol-1-ylmethyl)-5-(5-thiazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)-
1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-imidazol-1-ylmethyl)-5-(5-thiazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)-
1,2,4-pyrrolidinetricarboxylic acid, 2-(2-methylpropyl)-5-(2-thienyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S,4S,5R)-
1,2,4-pyrrolidinetricarboxylic acid, 2-(2-methylpropyl)-5-(5-thiazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S,4S,5R)-