2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
- Product Name
- 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
- CAS No.
- 62774-90-7
- Chemical Name
- 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
- Synonyms
- 2,6-dichloro-4-methylnicotinic;2,6-dichloro-4-methylnicotinic acid;2,6-Dichloro-4-methylnicotinicacid,98%;2,6-Dichloro-4-methyl-3-pyridinecarboxylic;2,6-Dichloro-4-methylpyridin-3-carboxylic acid;2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid;2,6-dichloro-4-methylpyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2,6-dichloro-4-Methyl-
- CBNumber
- CB91501257
- Molecular Formula
- C7H5Cl2NO2
- Formula Weight
- 206.03
- MOL File
- 62774-90-7.mol
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid Property
- Melting point:
- 140-141 °C
- Boiling point:
- 370.1±37.0 °C(Predicted)
- Density
- 1.522±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.55±0.38(Predicted)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C7H5Cl2NO2/c1-3-2-4(8)10-6(9)5(3)7(11)12/h2H,1H3,(H,11,12)
- InChIKey
- QOSNTWMXACGOMD-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC(C)=C1C(O)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D437093
- Product name
- 2,6-Dichloro-4-methyl-3-pyridinecarboxylicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D437093
- Product name
- 2,6-Dichloro-4-methyl-3-pyridinecarboxylicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- D437093
- Product name
- 2,6-Dichloro-4-methyl-3-pyridinecarboxylicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD139655
- Product name
- 2,6-Dichloro-4-methylnicotinic acid
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- 074345
- Product name
- 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid Chemical Properties,Usage,Production
Synthesis
875-35-4
62774-90-7
Method 2: Concentrated nitric acid (14 mL) was slowly added to concentrated sulfuric acid (43 mL) that had been pre-cooled to 0°C, ensuring that the temperature of the reaction system was maintained below 10°C. The reaction system was then heated to 70°C. The reaction system was then heated to 70°C. After addition, the mixed acid solution was warmed to 70 °C, followed by the addition of commercially available 2,6-dichloro-4-methylnicotinonitrile (20.0 g, 107 mmol). The heating was continued until the internal temperature of the reaction system reached 105°C. The heating was stopped. After 2 hours of reaction, TLC monitoring showed complete reaction. The reaction mixture was cooled to room temperature and quenched by slowly pouring into ice (100 g) under vigorous stirring. The precipitated solid was collected by filtration and washed with cold water (10 mL). The resulting solid was dissolved in ethyl acetate (100 mL) and the solution was dried over anhydrous sodium sulfate and concentrated to give 2,6-dichloro-4-methylnicotinic acid (21.0 g, 96% yield) as a white solid: Rf = 0.20 (unfolding reagent ratio 1:1 ethyl acetate/hexane solvent mixture).
References
[1] Patent: US6677352, 2004, B1. Location in patent: Page/Page column 46
[2] Chemistry of Heterocyclic Compounds, 2004, vol. 40, # 3, p. 308 - 314
[3] Journal of Organic Chemistry, 2000, vol. 65, # 10, p. 3111 - 3115
[4] Patent: WO2016/33009, 2016, A1. Location in patent: Page/Page column 17
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid Suppliers
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- sales@carbosynth.com
- Country
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View Lastest Price from 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid manufacturers
- Product
- 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid 62774-90-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-18