ChemicalBook > CAS DataBase List > 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid

2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid

Product Name
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
CAS No.
62774-90-7
Chemical Name
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
Synonyms
2,6-dichloro-4-methylnicotinic;2,6-dichloro-4-methylnicotinic acid;2,6-Dichloro-4-methylnicotinicacid,98%;2,6-Dichloro-4-methyl-3-pyridinecarboxylic;2,6-Dichloro-4-methylpyridin-3-carboxylic acid;2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid;2,6-dichloro-4-methylpyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2,6-dichloro-4-Methyl-
CBNumber
CB91501257
Molecular Formula
C7H5Cl2NO2
Formula Weight
206.03
MOL File
62774-90-7.mol
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2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid Property

Melting point:
140-141 °C
Boiling point:
370.1±37.0 °C(Predicted)
Density 
1.522±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
1.55±0.38(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C7H5Cl2NO2/c1-3-2-4(8)10-6(9)5(3)7(11)12/h2H,1H3,(H,11,12)
InChIKey
QOSNTWMXACGOMD-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC(C)=C1C(O)=O
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
D437093
Product name
2,6-Dichloro-4-methyl-3-pyridinecarboxylicacid
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
D437093
Product name
2,6-Dichloro-4-methyl-3-pyridinecarboxylicacid
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
D437093
Product name
2,6-Dichloro-4-methyl-3-pyridinecarboxylicacid
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD139655
Product name
2,6-Dichloro-4-methylnicotinic acid
Packaging
1g
Price
$84
Updated
2021/12/16
Matrix Scientific
Product number
074345
Product name
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
Purity
95+%
Packaging
5g
Price
$65
Updated
2021/12/16
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2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid Chemical Properties,Usage,Production

Synthesis

875-35-4

62774-90-7

Method 2: Concentrated nitric acid (14 mL) was slowly added to concentrated sulfuric acid (43 mL) that had been pre-cooled to 0°C, ensuring that the temperature of the reaction system was maintained below 10°C. The reaction system was then heated to 70°C. The reaction system was then heated to 70°C. After addition, the mixed acid solution was warmed to 70 °C, followed by the addition of commercially available 2,6-dichloro-4-methylnicotinonitrile (20.0 g, 107 mmol). The heating was continued until the internal temperature of the reaction system reached 105°C. The heating was stopped. After 2 hours of reaction, TLC monitoring showed complete reaction. The reaction mixture was cooled to room temperature and quenched by slowly pouring into ice (100 g) under vigorous stirring. The precipitated solid was collected by filtration and washed with cold water (10 mL). The resulting solid was dissolved in ethyl acetate (100 mL) and the solution was dried over anhydrous sodium sulfate and concentrated to give 2,6-dichloro-4-methylnicotinic acid (21.0 g, 96% yield) as a white solid: Rf = 0.20 (unfolding reagent ratio 1:1 ethyl acetate/hexane solvent mixture).

References

[1] Patent: US6677352, 2004, B1. Location in patent: Page/Page column 46
[2] Chemistry of Heterocyclic Compounds, 2004, vol. 40, # 3, p. 308 - 314
[3] Journal of Organic Chemistry, 2000, vol. 65, # 10, p. 3111 - 3115
[4] Patent: WO2016/33009, 2016, A1. Location in patent: Page/Page column 17

2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid Suppliers

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View Lastest Price from 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid 62774-90-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-18

62774-90-7, 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acidRelated Search:

2,6-DICHLORO-4-METHYLNICOTINAMIDE 2,6-Dichloro-5-fluoro-4-methylpyridine-3-carboxylic acid 2,6-Dichloro-4-methylpyridine-3-carboxaldehyde 2,5,6-TRICHLORO-4-METHYLNICOTINIC ACID 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid 2,6-Dichloronicotinic acid 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID 4-METHYLNICOTINIC ACID HYDROCHLORIDE

  • 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
  • 2,6-dichloro-4-methylnicotinic acid
  • 3-Pyridinecarboxylic acid, 2,6-dichloro-4-Methyl-
  • 2,6-dichloro-4-methylpyridine-3-carboxylic acid
  • 2,6-Dichloro-4-methylnicotinicacid,98%
  • 2,6-Dichloro-4-methyl-3-pyridinecarboxylic
  • 2,6-Dichloro-4-methylpyridin-3-carboxylic acid
  • 2,6-dichloro-4-methylnicotinic
  • 62774-90-7
  • pharmacetical
  • Heterocycle-Pyridine series