Methyl 3-chloroisonicotinate
- Product Name
- Methyl 3-chloroisonicotinate
- CAS No.
- 98273-79-1
- Chemical Name
- Methyl 3-chloroisonicotinate
- Synonyms
- Methyl 3-chloronicotinate;Methyl 3-chloroisonicotinate;Methyl 3-chloropyridine-4-carboxylate;3-Chloro-4-pyridinecarboxylic acid methyl ester;3-Chloropyridine-4-carboxylic acid methyl ester;4-Pyridinecarboxylic acid, 3-chloro-, methyl ester
- CBNumber
- CB91501631
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 98273-79-1.mol
Methyl 3-chloroisonicotinate Property
- Boiling point:
- 70-75℃ (0.1 Torr)
- Density
- 1.294±0.06 g/cm3(Predicted)
- refractive index
- 1.53425 (589.3 nm 20℃)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.83±0.18(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B495033
- Product name
- Methyl3-Chloroisonicotinate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B495033
- Product name
- Methyl3-Chloroisonicotinate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Y15205
- Product name
- Methyl3-chloroisonicotinate
- Purity
- 98%
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
- Product number
- Y15205
- Product name
- Methyl3-chloroisonicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- OR955631
- Product name
- Methyl3-chloroisonicotinate
- Purity
- 95%
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
Methyl 3-chloroisonicotinate Chemical Properties,Usage,Production
Synthesis
88912-27-0
74-88-4
98273-79-1
The general procedure for the synthesis of methyl 3-chloroisonicotinate from 3-chloropyridine-4-carboxylic acid and iodomethane was as follows: potassium carbonate (36.3 g, 263 mmol) was added to 3-chloropyridine-4-carboxylic acid (10.35 g, 65.7 mmol) dissolved in DMSO (50 mL). After 30 min of reaction, iodomethane (8.22 mL, 131 mmol) was slowly added. The reaction mixture was stirred continuously at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (300 mL) and deionized water (200 mL), followed by extraction with ethyl acetate (3 x 200 mL). The organic phases were combined, washed with brine (2 × 50 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. Purification by silica gel column chromatography with the eluent being a hexane solution of 10-30% ethyl acetate resulted in methyl 3-chloroisonicotinate as a colorless liquid (6.275 g, 56% yield). MS (electrospray positive ion mode) m/z: 172 ([M+H]+); LC retention time: 2.45 min (analytical conditions).
References
[1] Patent: WO2009/100171, 2009, A1. Location in patent: Page/Page column 70
[2] Synthetic Communications, 1997, vol. 27, # 6, p. 1075 - 1086
Methyl 3-chloroisonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 3-chloroisonicotinate Suppliers
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