3,3-DIFLUORO-CYCLOBUTANECARBONITRILE

Product Name: 3,3-DIFLUORO-CYCLOBUTANECARBONITRILE
CAS No.: 86770-80-1
Chemical Name: 3,3-DIFLUORO-CYCLOBUTANECARBONITRILE
Synonyms: 3,3-difluorocyclobutane-1-carbonitrile;3,3-DIFLUORO-CYCLOBUTANECARBONITRILE;Cyclobutanecarbonitrile, 3,3-difluoro-;3,3-Difluorocyclobutanecarbonitrile - D6209
CBNumber: CB91501873
Molecular Formula: C5H5F2N
Formula Weight: 117.1
MOL File: 86770-80-1.mol

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3,3-DIFLUORO-CYCLOBUTANECARBONITRILE Property

Boiling point:: 160.5±40.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
Appearance: Colorless to light yellow Solid
InChI: InChI=1S/C5H5F2N/c6-5(7)1-4(2-5)3-8/h4H,1-2H2
InChIKey: RCXLAPBURAMYKG-UHFFFAOYSA-N
SMILES: C1(C#N)CC(F)(F)C1

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Safety

HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D866080
Product name: 3,3-Difluorocyclobutanecarbonitrile
Packaging: 50mg
Price: $90
Updated: 2021/12/16

Activate Scientific

Product number: AS15100
Product name: 3,3-Difluorocyclobutane-1-carbonitrile
Purity: 97+%
Packaging: 250mg
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD104379
Product name: 3,3-difluorocyclobutane-1-carbonitrile
Packaging: 100mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: 1053AF
Product name: 3,3-Difluorocyclobutanecarbonitrile
Packaging: 1g
Price: $291
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD104379
Product name: 3,3-difluorocyclobutane-1-carbonitrile
Packaging: 250mg
Price: $300
Updated: 2021/12/16

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3,3-DIFLUORO-CYCLOBUTANECARBONITRILE Chemical Properties,Usage,Production

Synthesis

20249-16-5

86770-80-1

The general procedure for the synthesis of 3,3-difluorocyclobutanecarbonitrile from 3-oxocyclobutanecarbonitrile was as follows: Example 125A (8.21 g, 86 mmol) was dissolved in dichloromethane (135 mL), stirred and cooled to <10 °C at room temperature. DAST (11.41 mL, 86 mmol) was slowly added, followed by warming the reaction mixture to room temperature. Stirring was continued at room temperature for 2 hours. Upon completion of the reaction, the mixture was poured into saturated aqueous NaHCO3 solution (200 mL) for quenching and partitioning. The aqueous phase was extracted with dichloromethane (2 x 50 mL). The organic phases were combined, dried over anhydrous Na2SO4, filtered and concentrated to give Example 125B (9.14 g, 78 mmol, 90% yield) as a brown oil. The product was characterized by XH NMR (400 MHz, CDC13) with chemical shifts of 3.06-2.91 (m, 5H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 13, p. 3947 - 3953
[2] Patent: WO2015/115673, 2015, A1. Location in patent: Page/Page column 88-89
[3] Patent: WO2013/62964, 2013, A2. Location in patent: Paragraph 1267; 1268
[4] Patent: US2014/80803, 2014, A1. Location in patent: Paragraph 1134
[5] Patent: US2017/50961, 2017, A1. Location in patent: Paragraph 1065; 1066; 1067; 1068

3,3-DIFLUORO-CYCLOBUTANECARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,3-DIFLUORO-CYCLOBUTANECARBONITRILE Suppliers

China 42 India 1 United Kingdom 1 United States 9 Global 53

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
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Amadis Chemical Company Limited

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View Lastest Price from 3,3-DIFLUORO-CYCLOBUTANECARBONITRILE manufacturers

Career Henan Chemical Co

Product: 3,3-DIFLUORO-CYCLOBUTANECARBONITRILE 86770-80-1
Price: US $5.00/KG
Min. Order: 1KG
Purity: 95%-98%
Supply Ability: 100kg
Release date: 2019-09-04

86770-80-1, 3,3-DIFLUORO-CYCLOBUTANECARBONITRILERelated Search:

1-CYANO-2,2,3,3-TETRAFLUOROCYCLOBUTANE 1,1,2-TRIFLUORO-2-CHLORO-3-CYANO CYCLOBUTANE 3,3-DIFLUORO-CYCLOBUTANECARBONITRILE

3,3-DIFLUORO-CYCLOBUTANECARBONITRILE

3,3-Difluorocyclobutanecarbonitrile - D6209

3,3-difluorocyclobutane-1-carbonitrile

Cyclobutanecarbonitrile, 3,3-difluoro-

86770-80-1