TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE

Product Name: TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE
CAS No.: 365996-05-0
Chemical Name: TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE
Synonyms: 7-dihydrothiazolo[5;tert-butyl 2-aMino-6;4-c]pyridine-5(4H)-carboxylate;2-AMino-5-Boc-6,7-dihydro-4H-thiazolo-[5,4,c]pyridine;4,5,6,7-tetrahydro-5-Boc-thiazolo[5,4-c]pyridin-2-amine;5-Boc-2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine;tert-butyl 2-amino-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5...;tert-butyl 2-aMino-6.7-dihydrothiazolo[5.4-c]pyridine-5(4H)-carb;tert-butyl 2-amino-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylate;2-Amino-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine, N5-BOC protected
CBNumber: CB91501954
Molecular Formula: C11H17N3O2S
Formula Weight: 255.34
MOL File: 365996-05-0.mol

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TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Property

Melting point:: 91-94 °C
Boiling point:: 412.8±45.0 °C(Predicted)
Density: 1.279±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Crystalline Powder
pka: 5.23±0.20(Predicted)
color: Off-white to brown
InChI: InChI=1S/C11H17N3O2S/c1-11(2,3)16-10(15)14-5-4-7-8(6-14)17-9(12)13-7/h4-6H2,1-3H3,(H2,12,13)
InChIKey: BMLHPGOMLGKYIJ-UHFFFAOYSA-N
SMILES: C1N(C(OC(C)(C)C)=O)CCC2N=C(N)SC1=2

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: A630045
Product name: 2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carboxylicAcidtert-ButylEster
Packaging: 5g
Price: $590
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-1-V6
Product name: 2-Amino-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine, N5-Boc protected
Packaging: 1g
Price: $66
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143127
Product name: tert-Butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
Packaging: 500mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143127
Product name: tert-Butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
Packaging: 1g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143127
Product name: tert-Butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
Packaging: 2g
Price: $209
Updated: 2021/12/16

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TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Chemical Properties,Usage,Production

Uses

2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carboxylic Acid tert-Butyl Ester is a reagent used in the synthesis of 2-(thiazol-2-amino)-4-arylaminopyrimidines, which are anaplastic lymphoma kinase (ALK) inhibitors.

Synthesis

420-04-2

79099-07-3

365996-05-0

To a 100 mL single-necked flask were added N-Boc-4-piperidone (10 g, 50 mmol), sulfur powder (3.22 g, 100 mmol), cyanamide (4.36 g, 100 mmol), and pyridine (40 mL). The reaction mixture was heated to 130 °C and kept for 90 min. After completion of the reaction, it was cooled to room temperature and the solid product was collected by filtration. The solid was washed with ethyl acetate and dried to give the dark brown solid product tert-butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (9.7 g, 76% yield).

References

[1] Patent: CN105254613, 2016, A. Location in patent: Paragraph 0339; 0340; 0341
[2] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 128 - 152
[3] Patent: WO2014/113191, 2014, A1. Location in patent: Paragraph 0124; 0125
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 9, p. 3687 - 3706
[5] Heterocycles, 2004, vol. 63, # 7, p. 1555 - 1561

TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Suppliers

China 151 China Hong Kong 1 Germany 1 India 2 United Kingdom 3 United States 20 Global 178

Shanghai Tengyi Chemical Technology Co., Ltd.

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Shangchem Co., Ltd.

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Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
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Wuhan Luohua Medical Technology Co.,Ltd.

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View Lastest Price from TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE 365996-05-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-03

365996-05-0, TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATERelated Search:

tert-butyl 3-iodo-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE TERT-BUTYL 6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE 4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE 4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE SALT

Thiazolo[5,4-c]pyridine-5(4H)-carboxylic acid, 2-amino-6,7-dihydro-, 1,1-dimethylethyl ester

4,5,6,7-tetrahydro-5-Boc-thiazolo[5,4-c]pyridin-2-amine

2-Amino-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester

4-c]pyridine-5(4H)-carboxylate

7-dihydrothiazolo[5

tert-butyl 2-aMino-6

tert-butyl 2-aMino-6.7-dihydrothiazolo[5.4-c]pyridine-5(4H)-carb

2-AMino-5-Boc-6,7-dihydro-4H-thiazolo-[5,4,c]pyridine

tert-butyl 2-aMino-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

5-Boc-2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

2-Amino-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine, N5-BOC protected

tert-Butyl 2-amino-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carboxylate, 2-Amino-5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

tert-butyl 2-amino-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylate

tert-butyl 2-amino-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

ENCHEM TERT-BUTYL 2-AMINO-6,7-DIHYDRO[1,3]THIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE 365996-05-0

tert-butyl 2-amino-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5...

1,1-Dimethylethyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

365996-05-0

Heterocycle-Pyridine series

CHIRAL CHEMICALS