ChemicalBook > CAS DataBase List > 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
- Product Name
- 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
- CAS No.
- 356068-93-4
- Chemical Name
- 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
- Synonyms
- Malate Sunitinib Impurities A;Des-N-(2-Diethylaminoethyl)amide Sunitinib Acid;5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl...;Cefatrizine Propylene Glycol Impurity 1(Cefatrizine Propylene Glycol EP Impurity A);(Z)-5-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]-2,4-dimethylpyrrole-3-carboxylic Acid;(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrol-3-carboxylic acid;(Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxylic acid;5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid;5-((z)-(5-fluoro-2-oxindolin-3-ylidine)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid;(3Z)-3-[(3,5-Dimethyl-4-carboxy-1H-pyrrol-2-yl)methylidene]-5-fluoro-1,3-dihydro-2H-indol-2-on
- CBNumber
- CB91503983
- Molecular Formula
- C16H13FN2O3
- Formula Weight
- 300.28
- MOL File
- 356068-93-4.mol
More
Less
5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Property
- Melting point:
- 320 °C (decomp)
- Boiling point:
- 588.4±50.0 °C(Predicted)
- Density
- 1.454±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated)
- form
- Solid
- pka
- 5.79±0.50(Predicted)
- color
- Dark Orange
- InChI
- InChI=1S/C16H13FN2O3/c1-7-13(18-8(2)14(7)16(21)22)6-11-10-5-9(17)3-4-12(10)19-15(11)20/h3-6,18H,1-2H3,(H,19,20)(H,21,22)/b11-6-
- InChIKey
- RBHBOUYXUXWCNJ-WDZFZDKYSA-N
- SMILES
- N1C(/C=C2/C3=C(NC/2=O)C=CC(F)=C3)=C(C)C(C(O)=O)=C1C
More
Less
N-Bromosuccinimide Price
AK Scientific
- Product number
- Y6605
- Product name
- 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid
- Packaging
- 250mg
- Price
- $139
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M1922
- Product name
- (Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid
- Packaging
- 1g
- Price
- $173
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M1922
- Product name
- (Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid
- Packaging
- 5g
- Price
- $583
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0415789
- Product name
- 5-((Z)-(5-FLUORO-2-OXOINDOLIN-3-YLIDENE)METHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $768.08
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M1922
- Product name
- (Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid
- Packaging
- 10g
- Price
- $828
- Updated
- 2021/12/16
More
Less
5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Brown crystals
Uses
Des-N-(2-Diethylaminoethyl)amide Sunitinib Acid is an impurity of Sunitinib (S819995), a multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Antineoplastic.
Synthesis
253870-02-9
56341-41-4
356068-93-4
Ammonium sulfate ((NH4)2SO4, 0.09 g, 0.67 mmol) was added to hexamethyldisilazane (HMDS, 20 mL) as 2,4-dimethyl-5-formyl-1H-pyrrole-3-carboxylic acid (8, 1.0 g, 6.61 mmol) and 5-fluoroindol-2-one (14, 1.1 g, 3.77 mmol) at room temperature in a stirred mixture. Subsequently, the reaction mixture was heated to reflux and maintained at this temperature for at least 5 h. The reaction process was monitored by gas chromatography (GC). Upon completion of the reaction, 5-fluoroindol-2-one (14) and trimethylsilyl trifluoromethanesulfonate (TMSOTf, 0.29 g, 1.32 mmol) were added. Stirring of the mixture was continued until high performance liquid chromatography (HPLC) analysis showed that the reaction was complete. The reaction mixture was quenched with water (6 mL) and acetonitrile (MeCN, 30 mL), filtered and the filter cake was washed sequentially with acetonitrile (20 mL) and ethanol (EtOH, 5 mL). Finally, the product was dried under vacuum at 40 °C overnight to afford the target compound 5-((Z)-(5-fluoro-2-oxoindolidine-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (15, 1.92 g, 97% yield) as a yellow to brown powder with an HPLC purity of about 82.1%.
References
[1] Patent: US2013/190512, 2013, A1. Location in patent: Paragraph 0088
[2] Patent: WO2007/81560, 2007, A2. Location in patent: Page/Page column 6
[3] Patent: WO2006/127961, 2006, A1. Location in patent: Page/Page column 15-16
[4] Patent: WO2008/33562, 2008, A2. Location in patent: Page/Page column 34
[5] Patent: US2009/76005, 2009, A1. Location in patent: Page/Page column 12; 13
5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Suppliers
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16077
- Advantage
- 64
- Tel
- 86+28-85337952 18081025021
- Fax
- 86+28-85337952
- greenyoung@glykj.com
- Country
- China
- ProdList
- 94
- Advantage
- 62
- Tel
- 0510-83588313-811 18800520310
- sales@chemshuttle.com
- Country
- China
- ProdList
- 2999
- Advantage
- 62
- Tel
- 15062859468
- Fax
- QQ:1719657062，MSN:quality.kate@hotmail.com
- Country
- China
- ProdList
- 100
- Advantage
- 58
- Tel
- 025-58196018 800028039
- Fax
- 025-83453306
- sales@fartop.net
- Country
- China
- ProdList
- 2229
- Advantage
- 55
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-58958002 18930822973
- Fax
- +86 (21) 5895-8628
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 998
- Advantage
- 58
- Tel
- +86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
- Fax
- +86 (20) 39218032
- Country
- China
- ProdList
- 454
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 025-83172655 13585105703
- Fax
- +86-25-86501191
- sales@njfirstpharm.com
- Country
- China
- ProdList
- 110
- Advantage
- 60
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- 18663683121
- Fax
- 0536-8858983
- dhpharm@163.com
- Country
- China
- ProdList
- 31
- Advantage
- 58
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4613
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6479
- Advantage
- 50
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 021-34621078 13120882795
- Fax
- 021-34622517
- 465106944@qq.com
- Country
- China
- ProdList
- 857
- Advantage
- 56
- Tel
- 13585175604 13057662806
- Fax
- +86-25-52261140
- sales@chicopharm.com
- Country
- China
- ProdList
- 500
- Advantage
- 65
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 0715-8108888-8009
- Fax
- -
- 3032618938@qq.com
- Country
- China
- ProdList
- 47
- Advantage
- 56
- Tel
- 028-86040038 13980902949;
- Fax
- 028-85149890
- market@dingdangchem.com
- Country
- China
- ProdList
- 1853
- Advantage
- 55
- Tel
- 025-87193546 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 9021
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- 18221735425
- sales@xinpingchem.com
- Country
- China
- ProdList
- 9942
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-34053660
- Fax
- QQ:2881074831
- sale2@labgogo.com
- Country
- China
- ProdList
- 2018
- Advantage
- 58
- Tel
- 0512-68131995 13862051930
- Fax
- 0512-68131995
- Country
- China
- ProdList
- 360
- Advantage
- 55
- Tel
- 17836913271
- Fax
- 0374-8348899
- 3224305243@qq.com
- Country
- China
- ProdList
- 2952
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 0531-61320525 15866703830
- figo.gao@foxmail.com
- Country
- China
- ProdList
- 5177
- Advantage
- 58
- Tel
- 0371-67991738 13783628208
- Fax
- QQ 412703949
- carl@alchemist-pharm.com
- Country
- China
- ProdList
- 1872
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10295
- Advantage
- 58
- Tel
- 0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 9972
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 010-82387566 18001021521;
- Fax
- 82387566-801
- sales@mreda.com.cn
- Country
- China
- ProdList
- 10083
- Advantage
- 58
- Tel
- 13316949107 13316968096
- 1979313431@qq.com
- Country
- China
- ProdList
- 9564
- Advantage
- 58
- Tel
- 0371-55055611 18137792234
- Fax
- QQ：3002694073
- 3002694073@qq.com
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- +86-27-8746-5837 +8619945049750
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9629
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12373
- Advantage
- 58
- Tel
- +86-0571-81612335 +8613336028439
- sales@nextpeptide.com
- Country
- China
- ProdList
- 19908
- Advantage
- 58
More
Less
View Lastest Price from 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 356068-93-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
Career Henan Chemical Co
- Product
- 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 356068-93-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22