(S)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate
- Product Name
- (S)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate
- CAS No.
- 158406-99-6
- Chemical Name
- (S)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate
- Synonyms
- (S)-1-Boc-3-broMoMethylpiperidine;(S)-N-Boc-3-(bromomethyl)piperidine;tert-butyl (s)-3-(bromomethyl)piperidine-1-carboxylate;tert-butyl (3S)-3-(bromomethyl)piperidine-1-carboxylate;(S)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate;(S)-3-Bromomethyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 3-(bromomethyl)-, 1,1-dimethylethyl ester, (3S)-
- CBNumber
- CB91508423
- Molecular Formula
- C11H20BrNO2
- Formula Weight
- 278.19
- MOL File
- 158406-99-6.mol
(S)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate Property
- Boiling point:
- 318.3±15.0 °C(Predicted)
- Density
- 1.270±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.03±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 4H56-9-S1
- Product name
- tert-Butyl (3S)-3-(bromomethyl)piperidine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 7952AA
- Product name
- (S)-tert-Butyl3-(bromomethyl)piperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $291
- Updated
- 2021/12/16
- Product number
- 113077
- Product name
- (S)-1-Boc-3-bromomethylpiperidine
- Packaging
- 1g
- Price
- $473
- Updated
- 2021/12/16
- Product number
- 4H56-9-S1
- Product name
- tert-Butyl (3S)-3-(bromomethyl)piperidine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $790
- Updated
- 2021/12/16
- Product number
- 4H56-9-S1
- Product name
- tert-Butyl (3S)-3-(bromomethyl)piperidine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 5G
- Price
- $1290
- Updated
- 2021/12/16
(S)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
140695-84-7
158406-99-6
General procedure for the synthesis of tert-butyl (S)-3-(bromomethyl)piperidine-1-carboxylate from tert-butyl (S)-3-(hydroxymethyl)piperidine-1-carboxylate: tert-butyl (S)-3-(hydroxymethyl)piperidine-1-carboxylate (30.0 g, 139 mmol) and carbon tetrabromide (72.0 g, 217 mmol) were dissolved in dichloromethane (150 mL). A solution of triphenylphosphine (42.4 g, 162 mmol) in dichloromethane (150 mL) was slowly added dropwise under ice bath cooling, keeping the internal temperature of the reaction system between 20 and 25 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at room temperature for 1 hour. Subsequently, cyclohexane (500 mL) was added and about half of the solvent was removed by evaporation under reduced pressure. The remaining solution was cooled in an ice bath and filtered to remove the resulting precipitate. The filtrate was concentrated under reduced pressure and the resulting residue was purified by fast column chromatography (eluent: 0 to 25% ethyl acetate/hexane, silica gel as stationary phase) to afford 35.1 g (91% yield) of tert-butyl (S)-3-(bromomethyl)piperidine-1-carboxylate as a solid. Mass spectrum (electrospray positive ion mode) m/z 278 ([M+H]+).
References
[1] Patent: WO2007/58850, 2007, A2. Location in patent: Page/Page column 41
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 18, p. 5663 - 5679
[3] Patent: WO2008/121685, 2008, A1. Location in patent: Page/Page column 38
[4] Patent: US2008/176901, 2008, A1. Location in patent: Page/Page column 9-10
(S)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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