2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE

Product Name: 2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE
CAS No.: 150054-50-5
Chemical Name: 2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE
Synonyms: 4-Chloro-3,5-dimethyl-2-pyridinemethanol;2-Pyridinemethanol, 4-chloro-3,5-dimethyl-;(4-chloro-3,5-dimethylpyridin-2-yl)methanol;2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE;2-Hydroxy Methyl-3, 5-Dimethyl-4-Methoxy Pyridine.[Intermediate For Omeprazole]
CBNumber: CB91511760
Molecular Formula: C8H10ClNO
Formula Weight: 171.62
MOL File: 150054-50-5.mol

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2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0356210
Product name: (4-CHLORO-3,5-DIMETHYLPYRIDIN-2-YL)METHANOL
Purity: 95.00%
Packaging: 5MG
Price: $501.23
Updated: 2021/12/16

AK Scientific

Product number: 3037CR
Product name: (4-Chloro-3,5-dimethylpyridin-2-YL)methanol
Packaging: 250mg
Price: $141
Updated: 2021/12/16

Ambeed

Product number: A225732
Product name: (4-Chloro-3,5-dimethylpyridin-2-yl)methanol
Purity: 95+%
Packaging: 1g
Price: $201
Updated: 2021/12/16

Chemenu

Product number: CM249657
Product name: (4-Chloro-3,5-dimethylpyridin-2-yl)methanol
Purity: 95%
Packaging: 1g
Price: $204
Updated: 2021/12/16

Alichem

Product number: 150054505
Product name: (4-Chloro-3,5-dimethylpyridin-2-yl)methanol
Packaging: 1g
Price: $220
Updated: 2021/12/16

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2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE Chemical Properties,Usage,Production

Synthesis

109371-20-2

150054-50-5

The general procedure for the synthesis of (4-chloro-3,5-dimethylpyridin-2-yl)methanol from 4-chloro-2,3,5-trimethylpyridine-1-oxide was as follows: 4-chloro-2,3,5-trimethylpyridine-N-oxide (60.0 g, 350 mmol) was dissolved in toluene (920 mL) and heated to 90-95 °C. Maintaining the temperature at about 60 °C, acetic anhydride (232 mL) was slowly added and the reaction lasted for 7 hours. Subsequently, the reaction mixture was concentrated under vacuum at about 60°C until 820 mL of solvent was distilled. Toluene (840 mL) was added and the solvent (940 mL) was again distilled off. Next, toluene (180 mL) and 40% NaOH aqueous solution (80 mL) were added and the reaction mixture was heated at 50°C for about 15 hours. After the reaction was completed, saturated aqueous sodium bicarbonate solution (120 mL) was added to separate the organic and aqueous phases. The aqueous phase was extracted again with toluene (80 mL). The organic phases were combined, washed with saturated aqueous sodium bicarbonate (120 mL), and then evaporated to dryness to afford 4-chloro-2-hydroxymethyl-3,5-dimethylpyridine as a brown oil, which solidified on standing. The yield was 61.8 g (quantitative). The product was analyzed by 1H-NMR (200 MHz, DMSO-d6) and LC-MS to confirm: 1H-NMR δ= 2.30 (s, 3H), 2.36 (s, 3H), 4.58 (br s, 2H), 5.11 (br s, 1H), 8.27 (s, 1H); LC-MS: MH+ = 172/174.

References

[1] Patent: WO2007/12650, 2007, A1. Location in patent: Page/Page column 28

2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE Suppliers

Canada 1 China 33 India 2 United States 1 Global 37

Wuhan Kaymke Chemical Co., Ltd.,

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ROSEWA HOLDING GROUP CO.,LIMITED

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150054-50-5, 2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINERelated Search:

4-CHLORO-3,5-DIMETHYLPYRIDINE 4-Chloro-2,3,5-trimethylpyridine 2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE

2-Hydroxy Methyl-3, 5-Dimethyl-4-Methoxy Pyridine.[Intermediate For Omeprazole]

(4-chloro-3,5-dimethylpyridin-2-yl)methanol

2-HYDROXYMETHYL-3,5-DIMETHYL -4-CHLORO PYRIDINE

4-Chloro-3,5-dimethyl-2-pyridinemethanol

2-Pyridinemethanol, 4-chloro-3,5-dimethyl-

150054-50-5