ChemicalBook > CAS DataBase List > LASOFOXIFENE HCL

LASOFOXIFENE HCL

Product Name: LASOFOXIFENE HCL
CAS No.: 190791-29-8
Chemical Name: LASOFOXIFENE HCL
Synonyms: Lasofoxifene tartrate;Oporia;Cb 336156eb;Unii-85X09V2gso;LASOFOXIFENE HCL;CP-336,156 tartrate;Lasofoxifene Tartrate, 10 mM in DMSO;(-)-cis-6-Phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol tartrate;(5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol tartrate;(5r,6s)-6-phenyl-5-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6,7,8-tetrahydronaphthalen-2-ol (2r,3r)-2,3-dihydroxysuccinate
CBNumber: CB91516053
Molecular Formula: C32H37NO8
Formula Weight: 563.65
MOL File: 190791-29-8.mol

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LASOFOXIFENE HCL Property

Melting point:: 185 °C(dec.)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to beige

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Safety

WGK Germany: 3
HS Code: 2933.99.7500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1026
Product name: Lasofoxifene tartrate
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $123
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1026
Product name: Lasofoxifene tartrate
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $489
Updated: 2025/07/31

TCI Chemical

Product number: L0336
Product name: Lasofoxifene Tartrate
Packaging: 10MG
Price: $78
Updated: 2025/07/31

TCI Chemical

Product number: L0336
Product name: Lasofoxifene Tartrate
Packaging: 50MG
Price: $238
Updated: 2025/07/31

Cayman Chemical

Product number: 17646
Product name: Lasofoxifene (tartrate)
Purity: ≥98%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

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LASOFOXIFENE HCL Chemical Properties,Usage,Production

Uses

disintegrant, enteric coating, sustained release formulations

Biological Activity

lasofoxifene (tartrate) is a third-generation, nonsteroidal selective estrogen receptor modulator (serm).estrogen receptors are activated by the hormone estrogen (17β-estradiol). serms are characterized by having estrogen agonist action in some tissues while acting as estrogen antagonists in others [1][2].lasofoxifene, also known as cp 336,156, is a third-generation, nonsteroidal selective estrogen receptor modulator. lasofoxifene bound with high affinity to the human estrogen receptor-α with ic50 value of 1.5 nm [1]. lasofoxifene is also a cb2 inverse agonist [4].in aged female rats, lasofoxifene decreased total serum cholesterol and fat body mass, and no uterine hypertrophy was observed. in 5-month-old ovariectomized (ovx) sprague-dawley female rats, lasofoxifene completely prevented ovx-induced increases in body weight gain, total serum cholesterol, and serum osteocalcin. cp-336,156 completely prevented ovx-induced bone loss and inhibited the increased bone turnover associated with estrogen deficiency in lumbar vertebrae, proximal tibiae, and distal femora [1].in postmenopausal women with osteoporosis, lasofoxifene reduced risks of nonvertebral and vertebral fractures, er-positive breast cancer, coronary heart disease, and stroke but an increased risk of venous thromboembolic events [2][3].

Biochem/physiol Actions

Lasofoxifene is a third-generation selective estrogen receptor modulator (SERM).

in vivo

Lasofoxifene tartrate (4 mg/mice; s.c.; 5 day/week; for 43 d) decreases arthritis severity, by reducing cartilage oligomeric matrix protein (COMP), the serum marker of cartilage destruction and reducing serum IL-6 (inflammatory cytokine) levels^[1].
Lasofoxifene tartrate (4 mg/mice; s.c.; 5 day/week; for 43 d) protects against generalised bone loss in CIA by increasing trabecular bone mineral density (BMD), cortical thickness in mice^[1].
Lasofoxifene tartrate (5, and 10 mg/kg; s.c.; 5 day/week; for 70 d) exerts function of inhibiting primary tumor growth and reducing metastases to the lung and the liver in mice^[3].

Animal Model:	Post-menopausal RA model on OVX (ovariectomised) DBA/1 mice (female DBA/1 mice, 8-10 weeks old, CIA-treated)^[1]
Dosage:	4 mg/mouse/day
Administration:	Subcutaneous injection; 5 days a week from the first signs of arthritis (day 18); 43 days
Result:	Reduced in arthritis severity, including synovial inflammation and destruction of joints reduction. The mean arthritis frequency was 47% while the vehicle group was 81% at 42 days post immunization.

Animal Model:	NSG mices with xenograft tumors model (MIND, mammary intraductal): WT, Y537S and D538G ERα render tumors^[3]
Dosage:	1, 5, or 10 mg/kg
Administration:	Subcutaneous injection; 5 days per week; for 70 days
Result:	Elicited a superior inhibitory effect at a dose of 10 mg/kg, resulted potential tumor shrinkage in Y537S and D538G tumors. And also reduced tumor weight to 60% for Y537S and 50% for D538G at 5 and 10 mg/kg, respectively.

References

[1]. ke hz, paralkar vm, grasser wa, et al. effects of cp-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models. endocrinology. 1998 apr;139(4):2068-76.
[2]. cummings sr, ensrud k, delmas pd, et al. lasofoxifene in postmenopausal women with osteoporosis. n engl j med. 2010 feb 25;362(8):686-96.
[3]. gennari l, merlotti d, nuti r. selective estrogen receptor modulator (serm) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene. clin interv aging. 2010 feb 2;5:19-29.
[4]. kumar p, song zh. cb2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene. biochem biophys res commun. 2014 jan 3;443(1):144-9.

LASOFOXIFENE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LASOFOXIFENE HCL manufacturers

Career Henan Chemical Co

Product: LASOFOXIFENE HCL 190791-29-8
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-10

190791-29-8, LASOFOXIFENE HCLRelated Search:

Propanolol D(-)-Tartaric acid Anastrozole Lenalidomide Metoprolol tartrate Lasofoxifene Dacomitinib (PF299804)

2-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-5-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-, (5R,6S)-, (2S,3S)-2,3-dihydroxybutanedioate (1:1) (salt)

2-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-5-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-, (5R-cis)-, (S-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt)

Cb 336156eb

Unii-85X09V2gso

(5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol (2S,3S)-2,3-dihydroxybutanedioate (1:1)

Lasofoxifene tartrate

(-)-cis-6-Phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol tartrate

(5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol tartrate

CP-336,156 tartrate

LASOFOXIFENE HCL

Oporia

(5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol (2S,3S)-2,3-dihydroxybutanedioate

osteoporosis,inhibit,Estrogen Receptor/ERR,arthritis,CP 336156,endocrine resistant,breast cancer,Lasofoxifene Tartrate,CP336156,Inhibitor,selective oestrogen receptor modulators,tartrate,oestrogen,Lasofoxifene

Lasofoxifene Tartrate, 10 mM in DMSO

(5r,6s)-6-phenyl-5-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6,7,8-tetrahydronaphthalen-2-ol (2r,3r)-2,3-dihydroxysuccinate

190791-29-8

C28H31NO2C4H6O6

C28H32ClNO2

C4H6O6C28H31NO2