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2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide

Product Name
2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide
CAS No.
24522-30-3
Chemical Name
2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide
Synonyms
2-Cyano-N<;Leflunomide Impurity H;Leflunomide EP Impurity H;Teriflunomide EP Impurity B;2-Cyano-N-[4-(trifluoromethyl)pheny;2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide;AcetaMide, 2-cyano-N-[4-(trifluoroMethyl)phenyl]-;Leflunomide Impurity 8(Leflunomide EP Impurity H);2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide;Leflunomide EP Impurity H (Teriflunomide EP Impurity B)
CBNumber
CB91525680
Molecular Formula
C10H7F3N2O
Formula Weight
228.17
MOL File
24522-30-3.mol
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2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide Property

Melting point:
145-147℃
Boiling point:
386.3±42.0 °C(Predicted)
Density 
1.375±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.63±0.10(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3217
Product name
2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide
Purity
>98.0%(GC)
Packaging
1g
Price
$168
Updated
2025/07/31
TCI Chemical
Product number
C3217
Product name
2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide
Purity
>98.0%(GC)
Packaging
5g
Price
$504
Updated
2025/07/31
TRC
Product number
C982245
Product name
2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide
Packaging
10g
Price
$360
Updated
2021/12/16
Ark Pharm
Product number
P000695420
Product name
2-Cyano-N-(4-(trifluoromethyl)phenyl)acetamide
Purity
98%
Packaging
250mg
Price
$21
Updated
2021/12/16
Ark Pharm
Product number
P000695420
Product name
2-Cyano-N-(4-(trifluoromethyl)phenyl)acetamide
Purity
98%
Packaging
1g
Price
$53
Updated
2021/12/16
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2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide Chemical Properties,Usage,Production

Uses

2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide (Leflunomide EP Impurity H) is used to prepare aminothiophene carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers. It is also used to synthesize (1,2,3-triazol-4-yl)benzenamines as inhibitors against VEGF receptors 1 and 2.

Synthesis

455-14-1

372-09-8

24522-30-3

In 700 L of tetrahydrofuran, 63.4 kg of cyanoacetic acid was dissolved and stirred at room temperature and under nitrogen protection. The resulting solution was cooled to 0 to 10°C, followed by slow dropwise addition of N-methylmorpholine at the same temperature over about 1 hour. Next, 100.0 kg of 4-trifluoromethylaniline was added dropwise. Continuing at the same temperature, 91.3 kg of isopropyl chlorocarbonate was slowly added dropwise to the reaction mixture over about 1 hour. After the dropwise addition was completed, the reaction was continued with stirring for 1 to 2 hours. After completion of the reaction, 200 L of water was added to the reaction mixture, stirred and left to stratify. The organic layer (upper layer) was washed with 16.7% brine, followed by the addition of 400 L of isopropanol and concentrated under reduced pressure until the volume of liquid was reduced to 400 L. 400 L of isopropanol was added again, and the concentration was repeated under reduced pressure until the volume of liquid was 400 L. 100 L of isopropanol was added to the concentrated solution at 20 to 30 °C followed by a slow dropwise addition of 500 L of water at about 20 °C. The reaction was completed with the addition of 500 L of water. After completion of the dropwise addition, stirring was continued for 1 hour at the same temperature. The mixture was cooled to 0 to 10°C and stirred at that temperature for 1 hour. The precipitated crystals were collected by filtration and dried to give 134.5 kg of 2-cyano-N-(4-(trifluoromethyl)phenyl)acetamide (IV) in 95.0% yield.

References

[1] Patent: EP1609778, 2005, A1. Location in patent: Page/Page column 5; 8-9
[2] Patent: WO2017/103942, 2017, A1. Location in patent: Page/Page column 5; 7
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 23, p. 4608 - 4621
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 11, p. 4626 - 4635
[5] Journal of Medicinal Chemistry, 1991, vol. 34, # 11, p. 3295 - 3301

2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide Suppliers

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View Lastest Price from 2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide 24522-30-3
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-27
Career Henan Chemical Co
Product
2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide 24522-30-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2019-08-05

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