ChemicalBook > CAS DataBase List > 1-benzofuran-3-carboxylic acid

1-benzofuran-3-carboxylic acid

Product Name
1-benzofuran-3-carboxylic acid
CAS No.
26537-68-8
Chemical Name
1-benzofuran-3-carboxylic acid
Synonyms
3-Carboxybenzo[b]furan;3-Benzofurancarboxylic acid;1-benzofuran-3-carboxylic acid;Benzo[b]furan-3-carboxylic acid;Benzo[b]furan-3-carboxylicacid97%;Benzo[b]furan-3-carboxylic acid 97%;1-benzofuran-3-carboxylic acid(SALTDATA: FREE);3-Carboxybenzo[b]furan, 1-Benzofuran-3-carboxylic acid
CBNumber
CB91543086
Molecular Formula
C9H6O3
Formula Weight
162.14
MOL File
26537-68-8.mol
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1-benzofuran-3-carboxylic acid Property

Melting point:
162℃
Boiling point:
325.6±15.0 °C(Predicted)
Density 
1.363±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
3.19±0.10(Predicted)
color 
White
InChI
InChI=1S/C9H6O3/c10-9(11)7-5-12-8-4-2-1-3-6(7)8/h1-5H,(H,10,11)
InChIKey
BENJFDPHDCGUAQ-UHFFFAOYSA-N
SMILES
O1C2=CC=CC=C2C(C(O)=O)=C1
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Safety

HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B427363
Product name
1-benzofuran-3-carboxylicacid
Packaging
100mg
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
OR16562
Product name
Benzo[b]furan-3-carboxylicacid
Purity
97%
Packaging
250mg
Price
$102
Updated
2021/12/16
SynQuest Laboratories
Product number
2H21-1-X5
Product name
Benzo[b]furan-3-carboxylicacid
Purity
97%
Packaging
250mg
Price
$112
Updated
2021/12/16
Matrix Scientific
Product number
011562
Product name
1-Benzofuran-3-carboxylic acid
Packaging
500mg
Price
$195
Updated
2021/12/16
Apolloscientific
Product number
OR16562
Product name
Benzo[b]furan-3-carboxylicacid
Purity
97%
Packaging
1g
Price
$232
Updated
2021/12/16
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1-benzofuran-3-carboxylic acid Chemical Properties,Usage,Production

Synthesis

40800-90-6

26537-68-8

The general procedure for the synthesis of benzofuran-3-carboxylic acid from 3-(methoxymethylenyl)-2(3H)-benzofuranone was as follows: 152 g of o-hydroxyphenylacetic acid was added to a reaction flask, 500 g of acetic anhydride and 250 g of trimethyl orthoformate were added. The temperature of the reaction mixture was raised to 80-100 °C and the temperature was maintained for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give a yellow solid product. To this solid product, 500 g of methanol was added, stirred until completely dissolved, the temperature of the solution was controlled at 0-10 °C, and 180 g of 30% sodium hydroxide solution was slowly added dropwise. Subsequently, the reaction mixture was heated to 50-60°C and kept at this temperature for 3-6 hours. At the end of the reaction, methanol was recovered by distillation under reduced pressure. To the residue, 300 g of drinking water was added, the temperature of the solution was adjusted to below 30 °C, and 160 g of 30% hydrochloric acid was added slowly and dropwise to adjust the pH to 1-2. The mixture was cooled to 0-10 °C and allowed to stand for 3 hours for decantation. The precipitate was collected by filtration and the solid product was washed with cold water. Finally, the product was dried under vacuum to give 158 g of white solid benzofuran-3-carboxylic acid in 97.5% yield.

References

[1] Patent: CN108239054, 2018, A. Location in patent: Paragraph 0009; 0015; 0016; 0018; 0020; 0022; 0024

1-benzofuran-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-benzofuran-3-carboxylic acid manufacturers

Career Henan Chemical Co
Product
1-benzofuran-3-carboxylic acid 26537-68-8
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09

26537-68-8, 1-benzofuran-3-carboxylic acidRelated Search:

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  • 3-Carboxybenzo[b]furan
  • 3-Carboxybenzo[b]furan, 1-Benzofuran-3-carboxylic acid
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  • 26537-68-8