1,3-DIACETOXYINDOLE
- Product Name
- 1,3-DIACETOXYINDOLE
- CAS No.
- 16800-67-2
- Chemical Name
- 1,3-DIACETOXYINDOLE
- Synonyms
- AKOS 92481;AKOS AU36-M367;1,3-DIACETOXYINDOLE;INDOXYL 1,3-DIACETATE;N,O-1,3-DIACETOXYINDOLE;3-Indoxyl-1,3-diacetate;N-ACETYL-3-ACETOXYINDOLE;N-ACETYLINDOL-3-YL ACETATE;1-Acetylindol-3-yl Acetate;1-ACETYL-3-INDOLYL ACETATE
- CBNumber
- CB9154661
- Molecular Formula
- C12H11NO3
- Formula Weight
- 217.22
- MOL File
- 16800-67-2.mol
1,3-DIACETOXYINDOLE Property
- Melting point:
- 80 °C
- Boiling point:
- 345.3±15.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform, Ethyl Acetate, Methanol
- form
- Solid
- color
- Light Brown
- InChI
- InChI=1S/C12H11NO3/c1-8(14)13-7-12(16-9(2)15)10-5-3-4-6-11(10)13/h3-7H,1-2H3
- InChIKey
- DNVFBLDIZKYQPL-UHFFFAOYSA-N
- SMILES
- C(=O)(N1C2=C(C=CC=C2)C(OC(C)=O)=C1)C
- CAS DataBase Reference
- 16800-67-2(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A168010
- Product name
- N-Acetyl-3-acetoxyindole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FA17069
- Product name
- N-Acetyl-3-acetoxyindole
- Packaging
- 2g
- Price
- $254.4
- Updated
- 2021/12/16
- Product number
- FA17069
- Product name
- N-Acetyl-3-acetoxyindole
- Packaging
- 1g
- Price
- $139.9
- Updated
- 2021/12/16
- Product number
- 6092
- Product name
- N-Acetyl-3-acetoxyindole
- Packaging
- 1g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- FA17069
- Product name
- N-Acetyl-3-acetoxyindole
- Packaging
- 5G
- Price
- $462.5
- Updated
- 2021/12/16
1,3-DIACETOXYINDOLE Chemical Properties,Usage,Production
Chemical Properties
Light Brown Solid
Uses
An indole derivative
Uses
1,3-Diacetoxyindole is a useful synthetic intermediate.
Synthesis
Synthesis of 2-[(carboxymethyl)amino]benzoic acid (Intermediate-32): to a 500 mL two-necked RB flask equipped with a magnetic stirrer, o-aminobenzoic acid (20 g, 145 mmol) was added dropwise to a stirred solution of K2CO3 (83 g, 602 mmol) in water (140 mL), followed by chloroacetic acid (13.7 g, 145 mmol) dropwise under N2 atmosphere at room temperature for about 30 min. , 145 mmol) for about 30 minutes at room temperature under N2 atmosphere. The reaction material was then heated at 90C for 16 hours. After the reaction material was cooled to room temperature, the pH of the reaction material was adjusted to 4-5 using citric acid. the solids were then filtered and dried in a vacuum oven at 70C for 12 hours to produce Intermediate-32 (23 g) as a light brown solid.
Synthesis of N,O-1,3-diacetylindole (Intermediate-33): To a 500 mL two-necked RB flask equipped with a magnetic stirrer, acetic anhydride (110 mL, 1200 mmol) was slowly added to a stirred solution of triethylamine (170 mL, 1242 mmol) and Intermediate-32 (23 g, 117 mmol) at 0 C under an N2 atmosphere. 1200 mmol). The reaction material was stirred at room temperature for 5 hours and further heated at 80C for 16 hours. The reaction material was then cooled to 0C and extracted with ethyl acetate (4 x 150 mL). The organic layer was washed with brine solution, dried over Na2SO4 and concentrated. The crude material was purified by silica gel column elution with hexane:EtOAc to yield Intermediate-33 (5.5 g) as a brown solid.
1,3-DIACETOXYINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-DIACETOXYINDOLE manufacturers
- Product
- 1,3-DIACETOXYINDOLE 16800-67-2
- Price
- US $2.20-8.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons
- Release date
- 2025-07-08
- Product
- 1,3-DIACETOXYINDOLE 16800-67-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-21