4-(2,2,2-trifluoroethoxy)benzoic acid
- Product Name
- 4-(2,2,2-trifluoroethoxy)benzoic acid
- CAS No.
- 27914-56-3
- Chemical Name
- 4-(2,2,2-trifluoroethoxy)benzoic acid
- Synonyms
- VITAS-BB TBB010266;ART-CHEM-BB B030036;4-(2,2,2-trifluoroethoxy)benzoic acid;Benzoic acid, 4-(2,2,2-trifluoroethoxy)-;4-(2,2,2-Trifluoroethoxy)benzoic acid 95+%
- CBNumber
- CB91547877
- Molecular Formula
- C9H7F3O3
- Formula Weight
- 220.15
- MOL File
- 27914-56-3.mol
4-(2,2,2-trifluoroethoxy)benzoic acid Property
- Boiling point:
- 272.0±40.0 °C(Predicted)
- Density
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.28±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B585568
- Product name
- 4-(2,2,2-Trifluoroethoxy)benzoicAcid
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- V4878
- Product name
- 4-(2,2,2-Trifluoroethoxy)benzoicacid
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- PC500851
- Product name
- 4-(2,2,2-Trifluoroethoxy)benzoicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- 2621-3-0L
- Product name
- 4-(2,2,2-Trifluoroethoxy)benzoic acid
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
- Product number
- PC500851
- Product name
- 4-(2,2,2-Trifluoroethoxy)benzoicacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $254
- Updated
- 2021/12/16
4-(2,2,2-trifluoroethoxy)benzoic acid Chemical Properties,Usage,Production
Synthesis
76579-46-9
27914-56-3
General procedure for the synthesis of 4-(2,2,2-trifluoroethoxy)benzoic acid from 4-(2,2,2-trifluoroethoxy)benzaldehyde: 4-(2,2,2-trifluoroethoxy)benzoaldehyde (0.6 g, 2.94 mmol) was dissolved in methanol (5 ml), 50% w/v aqueous potassium hydroxide (1.2 ml) was added, and stirred at 65 °C. Subsequently, 30 wt% aqueous hydrogen peroxide solution (2.4 ml) was added dropwise over a period of 20 minutes. After dropwise addition, the reaction mixture was continued to be heated at 65°C for 10 minutes. After completion of the reaction, it was cooled to room temperature, acidified with 1 M hydrochloric acid and then extracted with ether (3 x 30 ml). The organic phases were combined, washed with brine (20 ml) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 4-(2,2,2-trifluoroethoxy)benzoic acid (0.59 g, 91% yield) as a light yellow solid, which could be used for subsequent experiments without further purification.
References
[1] Patent: JP5667058, 2015, B2. Location in patent: Paragraph 0481; 0482
[2] Molecular Crystals and Liquid Crystals (1969-1991), 1991, vol. 204, p. 77 - 89
4-(2,2,2-trifluoroethoxy)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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