1-(2-hydroxy-5-nitrophenyl)propan-1-one Property

Melting point:

93-94 °C

Boiling point:

299.3±25.0 °C(Predicted)

Density 

1.321±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

5.45±0.30(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1-(2-hydroxy-5-nitrophenyl)propan-1-one Chemical Properties,Usage,Production

Preparation

Preparation by Friedel–Crafts acylation of p-nitrophe-nol with propionyl chloride in nitrobenzene in the presence of aluminium chloride (36%)
Also obtained by Fries rearrangement of p-nitrophenyl propionate (m.p. 63–64°) in nitrobenzene in the presence of aluminium chloride at 125° for 5 h (23%)
Preparation by reaction of boron trichloride with 2-methoxy-5-nitropropiophe-none in methylene chloride, first at ?78°, then at r.t. for 14 h (92%). Also obtained by nitration of o-hydroxypropiophenone (23%), in acetic acid with fuming nitric acid, first at 0°, then at 60°
Also obtained by alkaline hydrolysis of 3-methyl-6-nitrochromone (m.p. 147–148°) (85%).